Biosynthetic study of polyether skeleton : functional analysis of epoxidase and epoxide hydrolase.
Project/Area Number |
21710213
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Living organism molecular science
|
Research Institution | Hokkaido University |
Principal Investigator |
MINAMI Atsushi Hokkaido University, 大学院・理学研究院, 助教 (40507191)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ポリエーテル / 生合成 / エポキシド加水分解酵素 / エポキシ化酵素 / ラサロシド |
Research Abstract |
Functional analysis of two enzymes, epoxidase and epoxide hydrolase, involved in ionophore polyether biosynthesis advances our understanding of the enzymatic asymmetric epoxidation and epoxide-opening cascades. These findings open the door for the enzymatic synthesis of polyether skeleton.
|
Report
(3 results)
Research Products
(11 results)
-
[Journal Article] Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis.2011
Author(s)
Minami, A., Migita, A., Inada, D., Hotta, K., Watanabe, K., Oguri, H., Oikawa, H.
-
Journal Title
Related Report
Peer Reviewed
-
[Journal Article] Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis2011
Author(s)
Minami, A., Migita, A., Inada, D., Hotta, K., Watanabe, K., Oguri, H., Oikawa, H.
-
Journal Title
Organic Letters
Volume: 13
Pages: 1638-1641
Related Report
Peer Reviewed
-
-
-
-
[Presentation] Detailed Mechanism of Polyether Ring Formation Catalyzed by Epoxide Hydrolase Lsd19 involved in Lasalocid A biosynthesis2010
Author(s)
Minami, A., Migita, A., Inada, D., Watanabe, K., Oguri, H., Oikawa, H.
Organizer
PACIFICHEM 2010
Place of Presentation
Convention Center(ホノルル、米国)
Year and Date
2010-12-17
Related Report
-
-
-
-
-