Total synthesis of a natural HIV protease inhibitor and its partial structures
| Project/Area Number |
21710216
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Tohoku University |
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Principal Investigator |
FUWA Haruhiko 東北大学, 大学院・生命科学研究科, 准教授 (90359638)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | HIVプロテアーゼ / 全合成 / ディデムナケタール / 構造決定 / 天然物 / 構造活性相関 / 鈴木-宮浦反応 / 野崎-檜山-岸反応 / スピロアセタール / 天然物有機化学 / ライブラリー |
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| Research Abstract |
HIV protease is an enzyme responsible for the proteolysis of the polyprotein expressed by the retrovirus to produce matured proteins necessary for proliferation and infection. Thus, the inhibition of HIV protease represents an important therapeutic strategy for HIV-infected patients. In the present study, we have investigated synthetic routes toward marine natural products didemnaketals and their partial structures. We have completed the stereoselective syntheses of the C1-C11 acyclic domain and C9-C28 spiroacetal domain of didemnaketal B.
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Report
(3 results)
Research Products
(14 results)
