| Project/Area Number |
21710219
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
NAGUMO Yoko University of Tsukuba, 大学院・生命環境科学研究科, 助教 (70373339)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | タイトジャンクション / コフィリン / 生理活性 |
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| Research Abstract |
We previously found that capsaicin induces tight-junction (TJ) opening accompanied with cofilin activation in intestinal Caco-2 cells. In order to clarify the mechanism underlying the TJ opening action of capsaicin, I analyzed upstream and downstream of cofilin. As a result, I found proteins suggested to function leading to cofilin activation. In addition, I demonstrated that actin cytoskeleton, that is a direct target of cofilin, is remodeling together with some other proteins. I also investigated molecules which permeability is increased by capsaicin.
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