| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Intelligent nucleic acids that can release/capture particular drug depending on the condition were created by designing and modifying drug-binding aptamers. Moreover, modified nucleotides were enzymatically incorporated to them by the post-modification method. The incorporation efficiencies were varied significantly depending on sequences around 3'-end of oligonucleotides tethered and chemical structures of modified nucleotides incorporated, which could be improved to some extent, by use of genetically modified polymerases.
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