| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Theonellamides are known to recognize membrane sterol molecules and its consequences are unique cellular morphological changes. However, molecular mechanisms underlying the phenomena have not been clarified. In this study, we tried to uncover the mechanisms by genetic and chemical genetic approaches. We identified several genes/proteins whose mutation affected the sensitivity of cells to theonellamide, while some of them were revealed to be involved in an unknown system to orchestrate the events on/around the plasma membrane.
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