| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Organic compounds obtained from the ocean, so-called marine natural products, have received remarkable attention as drug candidate compounds due to their diverse and potent biological activities. Symbiodinolide, the polyol marine natural product with a molecular weight of 2860, has calcium channel opening activity and anti-HIV activity. Therefore, this molecule has been expected to be utilized as the novel medicine. In this research, synthetic study of symbiodinolide toward the structural elucidation has been performed, which has resulted in the synthesis and structural determination of the fragments corresponding to the half of the molecule.
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