Understanding and Evaluation of Alzheimer's Disease Using Glycan Profiles
| Project/Area Number |
21710238
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Seikei University |
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Principal Investigator |
TOTANI Kiichiro Seikei University, 理工学部, 准教授 (80360593)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 糖鎖 / ストレス / 小胞体 / アルツハイマー / 合成化学 |
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| Research Abstract |
Synthetic glycan substrates were treated with endoplasmic reticulum fractions extracted from model animals of Alzheimer's disease, dementia and osteoporosis. The resulting reconstructed glycan profiles were compared each other to understand these diseases by glycan processing change concerning with glycoprotein quality control. The results show that each glycan profile gives specific glycan rates for M8 glycan derivatives that have a different signal function for the each structural isomer. Since the each isomer means a signal of glycoprotein secretion and degradation, glycoprotein quality control were found to correlate with the candidate diseases.
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Report
(3 results)
Research Products
(76 results)
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[Journal Article] Sugar-binding activity of the MRH domain in the ER α-glucosidase II β subunit is important for efficient glucose trimming2009
Author(s)
Hu Dan, Yukiko Kamiya, Kiichiro Totani, Daiki Kamiya, Norihito Kawasaki, Daisuke Yamaguchi, Ichiro Matsuo, Naoki Matsumoto, Yukishige Ito, Koichi Kato, Kazuo Yamamoto
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Journal Title
Glycobiology 19
Pages: 1127-1135
Related Report
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[Journal Article] Sugar-binding activity of the MRH domain in the ER α-glucosidase II β subunitis important for efficient glucose trimming2009
Author(s)
Hu Dan, Yukiko Kamiya, Kiichiro Totani, Daiki Kamiya, Norihito Kawasaki, Daisuke Yamaguchi, Ichiro Matsuo, Naoki Matsumoto, Yukishige Ito, Koichi Kato, Kazuo Yamamoto
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Journal Title
Glycobiology 19
Pages: 1127-1135
Related Report
Peer Reviewed
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