| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Research Abstract |
Synthetic glycan substrates were treated with endoplasmic reticulum fractions extracted from model animals of Alzheimer's disease, dementia and osteoporosis. The resulting reconstructed glycan profiles were compared each other to understand these diseases by glycan processing change concerning with glycoprotein quality control. The results show that each glycan profile gives specific glycan rates for M8 glycan derivatives that have a different signal function for the each structural isomer. Since the each isomer means a signal of glycoprotein secretion and degradation, glycoprotein quality control were found to correlate with the candidate diseases.
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