Central action of lipid metabolism in the brain
| Project/Area Number |
21730595
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental psychology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
CHIKAHISA Sachiko The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (00452649)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 生理 / 脂質代謝 / 睡眠制御 / PPARs / AMPK / 中枢脂質代謝 |
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| Research Abstract |
We investigated the contribution of central energy metabolism to higher brain functions, focusing in particular on AMPK and PPARs. PPARs and AMPK are involved in the stimulation of lipid metabolism. We used several drugs that activate PPARs and AMPK. After injection of these drugs, sleep depth and anxiety level were changed. In addition, feeding schedule can alter sleep quality by affecting metabolic function. PPARs and AMPK may play a significant role in the interaction of lipid metabolism and brain function including sleep homeostasis and common neurobehavior.
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Report
(3 results)
Research Products
(19 results)
