Structure formation of biomembranes in molecular scale

• Project/Area Number: 21740308
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biophysics/Chemical physics
• Research Institution: The University of Tokyo
• Principal Investigator: NOGUCHI Hiroshi 東京大学, 物性研究所, 准教授 (00514564)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ソフトマターの物理 / 生物物理 / シミュレーション / ソフトマター物理

Research Abstract

We proposed an accurate estimation method of bending rigidity of biomembranes in molecular simulations. Our correction method for height fluctuation of planar membranes gives higher accuracy than the previous methods. We have found anisotropic surface tension of buckled membrane. This tension can be analytically derived using elliptic functions. We developed a novel coarse-grained model for lipid molecules, in which membrane properties can be varied over wide range.

Research Products

• [Journal Article] Solvent-free coarse-grained lipid model for large-scale simulations (2011)
  • Author(s): H. Noguchi
  • Journal Title: Journal of Chemical Physics Volume: 134 Issue: 5
  • DOI: 10.1063/1.3541246
  • Peer Reviewed
• [Journal Article] Anisotropic surface tension of buckled fluid membranes (2011)
  • Author(s): H. Noguchi
  • Journal Title: Physical Review Volume: E, 83 Issue: 6
  • DOI: 10.1103/physreve.83.061919
  • Peer Reviewed
• [Journal Article] Estimation of the bending rigidity and spontaneous curvature of fluid membranes in simulations (2011)
  • Author(s): H. Shiba and H. Noguchi
  • Journal Title: Physical Review Volume: E, 84 Issue: 3
  • DOI: 10.1103/physreve.84.031926
  • Peer Reviewed
• [Journal Article] Solvent-free coarse-grained lipid model for large-scale simulations (2011)
  • Author(s): H.Noguchi
  • Journal Title: Journal of Chemical Physics Volume: 134
  • Peer Reviewed
• [Journal Article] Dynamical Modes of Deformed Red Blood Cells and Lipid Vesicles in Flows (2010)
  • Author(s): H. Noguchi
  • Journal Title: Progress of Theoretical Physics Supplement Volume: 184 Pages: 364-368
  • NAID: 110007703101
  • Peer Reviewed
• [Journal Article] Dynamical modes of deformed red blood cells and lipid vesicles in flows (2010)
  • Author(s): H.Noguchi
  • Journal Title: Progress of Theoretical Physics Supplement (in press)
  • NAID: 110007703101
  • Peer Reviewed
• [Presentation] Dynamics of Lipid Membranes from Nano to Micro Meter Scales (2012)
  • Author(s): H. Noguchi
  • Organizer: Phase Transition Dynamics in Soft Matter : Bridging Microscale and Mesoscale(招待講演)
  • Place of Presentation: 京都大学(京都)
  • Year and Date: 2012-02-22
• [Presentation] Dynamics of Lipid Membranes from Nano to Micro Meter Scales (2012)
  • Author(s): H.Noguchi
  • Organizer: Phase Transition Dynamics in Soft Matter : Bridging Microscale and Mesoscale
  • Place of Presentation: 京都大学(京都)(招待講演)
  • Year and Date: 2012-02-22
• [Presentation] ナノからマイクロメートルスケールにおける生体膜のダイナミクス (2011)
  • Author(s): 野口博司
  • Organizer: 高分子計算機科学研究会(招待講演)
  • Place of Presentation: 東京大学(東京)
  • Year and Date: 2011-12-07
• [Presentation] ナノからマイクロメートルスケールにおける生体膜のダイナミクス (2011)
  • Author(s): 野口博司
  • Organizer: 高分子計算機科学研究会
  • Place of Presentation: 東京大学(東京)(招待講演)
  • Year and Date: 2011-12-07
• [Presentation] 脂質膜のバックリングにおける界面張力の異方性 (2011)
  • Author(s): 野口博司
  • Organizer: 日本物理学会2011年秋季大会
  • Place of Presentation: 富山大学(富山)
  • Year and Date: 2011-09-22
• [Presentation] Dynamics of lipid membranes in nano-to micro-meter scales (2011)
  • Author(s): H. Noguchi
  • Organizer: The 2nd international symposium on "Multi-scale Simulations of Biological and Soft Materials"
  • Place of Presentation: 京都大学(京都)
  • Year and Date: 2011-09-12
• [Presentation] Dynamics of lipid membranes in nano- to micro-meter scales (2011)
  • Author(s): H.Noguchi
  • Organizer: The 2nd international symposium on "Multi-scale Simulations of Biological and Soft Materials" (MSBSM 2011)
  • Place of Presentation: 京都大学(京都)
  • Year and Date: 2011-09-12
• [Presentation] Coarse-Grained Molecular Model to Simulate Bilayer Membrane in Large Scale (2010)
  • Author(s): H. Noguchi
  • Organizer: Multiscale modeling of lipid bilayers under equilibrium and non-equilibrium conditions(招待講演)
  • Place of Presentation: ローザンヌ(スイス)
  • Year and Date: 2010-10-29
• [Presentation] Coarse-Grained Molecular Model to Simulate Bilayer Membrane in Large Scale (2010)
  • Author(s): H.Noguchi
  • Organizer: CECAM Workshop : Multiscale modeling of lipid bilayers under equilibrium and non-equilibrium conditions
  • Place of Presentation: ローザンヌ(スイス)
  • Year and Date: 2010-10-29
• [Presentation] 膜の物理 (2010)
  • Author(s): 野口博司
  • Organizer: 第3回ソフトマター物理若手勉強会(講師)
  • Place of Presentation: 大阪府立大学(堺市)
  • Year and Date: 2010-09-25
• [Presentation] 粗視化脂質分子模型によるシミュレーション (2010)
  • Author(s): 野口博司
  • Organizer: 日本物理学会
  • Place of Presentation: 大阪府立大学(堺市)
  • Year and Date: 2010-09-25
• [Presentation] Simple Solvent-Free Molecular Model to Simulate Bilayer Membrane (2010)
  • Author(s): H. Noguchi
  • Organizer: ISSP International Workshop on Soft Matter Physics
  • Place of Presentation: 東京大学(柏市)
  • Year and Date: 2010-08-26
• [Presentation] 膜の物理 (2009)
  • Author(s): 野口博司
  • Organizer: 第3回ソフトマター物理若手勉強会(講師)
  • Place of Presentation: 筑波大学(つくば市)
  • Year and Date: 2009-09-04
• [Presentation] 膜の物理 (2009)
  • Author(s): 野口博司
  • Organizer: 第3回ソフトマター物理若手勉強会
  • Place of Presentation: 筑波大学(筑波市)
  • Year and Date: 2009-09-04
• [Remarks]
  • URL: http://noguchi.issp.u-tokyo.ac.jp/