Crosstalk between the local temperature change inside single living cells and the cellular functions
Project/Area Number |
21740316
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Biophysics/Chemical physics
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Research Institution | Waseda University |
Principal Investigator |
SUZUKI Madoka Waseda University, 総合研究機構, 講師 (40350475)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 生物物理 / 単一細胞 / 蛍光イメージング / 温度 / 熱 / 顕微鏡 |
Research Abstract |
The purpose of this study is to clarify the relationship between the temperature and the functions of the brain and the heart in which the [Ca^<2+>] strongly coupled with their function in the microscopic view point. We first focused on clarifying the thermal properties of single living cells. Then the effect of the local temperature gradient was studied with the use of dividing single HeLa cells. Furthermore, the response of the single motile cells to the local temperature gradient and the heat pulse was analyzed. In the meantime, the research was expanded to the studies to elucidate the mechanism of the oscillatory movement of the cardiac cell.
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Report
(3 results)
Research Products
(39 results)
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[Presentation] Microscopic heat pulse induced calcium dynamics in a migratory cell.2011
Author(s)
Itoh, H., Suzuki, M., Oyama, K., Motoyoshi, M., Ishiwata, S.
Organizer
Biophysical Society the 55th Annual Meeting
Place of Presentation
Baltimore, Maryland, USA
Year and Date
2011-03-09
Related Report
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[Presentation] Rearrangement of mitotic spindle in HeLa cell under steep temperature gradient.2011
Author(s)
Motoyoshi, M., Suzuki, M., Oyama, K., Itabashi, T., Ishiwata, S.
Organizer
Biophysical Society the 55th Annual Meeting
Place of Presentation
Baltimore, Maryland, USA
Year and Date
2011-03-09
Related Report
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[Presentation] Microscopic heat pulse induced calcium dynamics in a migratory cell.2011
Author(s)
Itoh, H., Suzuki, M., Oyama, K., Motoyoshi, M., Ishiwata, S.
Organizer
米国生物物理学会第55回年会(Biophysical Society the 55th Annual Meeting)
Place of Presentation
Baltimore, Maryland, USA
Related Report
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[Presentation] Rearrangement of mitotic spindle in HeLa cell under steep temperature gradient.2011
Author(s)
Motoyoshi, M., Suzuki, M., Oyama, K., Itabashi, T., Ishiwata, S.
Organizer
米国生物物理学会第55回年会(Biophysical Society the 55th Annual Meeting)
Place of Presentation
Baltimore, Maryland, USA
Related Report
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[Presentation] Fluorescence imaging of a heat transfer in single HeLa cells.2010
Author(s)
Oyama, K., Suzuki, M., Tseeb, V., Seto, Y., Motoyoshi, M., Itoh, H., Iwai, K., Ishiwata, S.
Organizer
The 1st Anniversary Symposium of Waseda Bioscience Research Institute in Singapore (WABIOS)
Place of Presentation
Singapore
Year and Date
2010-09-15
Related Report
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[Presentation] High-speed imaging of heat transfer in single living cells.2010
Author(s)
Oyama, K., Suzuki, M., Tseeb, V., Seto, K., Motoyoshi, M., Itoh, H., Iwai, K., Ishiwata, S.
Organizer
The 48th Annual Meeting of the Biophysical Society of Japan
Place of Presentation
Sendai
Related Report
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[Presentation] Ca^<2+> response to microscopic heat pulses in a migrant cell.2010
Author(s)
Itoh, H., Suzuki, M., Oyama, K., Motoyoshi, M., Seto, Y., Ishiwata, S.
Organizer
The 48th Annual Meeting of the Biophysical Society of Japan
Place of Presentation
Sendai
Related Report
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[Presentation] Self-organization in Biomotile Systems-Molecular motors, Auto-oscillation (SPOC) in muscle and Meiotic spindle-2010
Author(s)
Y.Oguchi, S.V.Mikhailenko, M.Suzuki, K.Sato, M.Ohtaki, Y.Shimamoto, K.Suzuki, J.Takagi, T.Itabashi
Organizer
1st POSTECH Workshop on Physics of Self-Organization in Bio/Nano-Systems, Asia Pacific Center for Theoretical Physics (APCTP), Pohang, S.Korea
Related Report
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[Presentation] Chemo-mechanical Feedback Loop in Biomotile Systems, International Conference on Physics Biology Interface2009
Author(s)
S.Ishiwata, Y.Oguchi, S.V.Mikhailenko, M.Suzuki, K.Sato, M.Ohtaki, Y.Shimamoto, K.Suzuki, J.Takagi, T.Itabashi
Organizer
Saha Institute of Nuclear Physics
Place of Presentation
Kolkata, India
Related Report
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[Presentation] 細胞内の局所的な温度変化の測定とその解析Measurement and analysis of local temperature change inside living cells.2009
Author(s)
Oyama, K., Suzuki, M., Tseeb, V., Ono, F., Seto, Y., Motoyoshi, M., Iwai, K., Ishiwata, S.
Organizer
日本生物物理学会第47回年会
Place of Presentation
徳島
Related Report
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