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The elucidation of color-tuning mechanism in Human red, green, and blue visual pigments and its application to medicine and engineering

Research Project

Project/Area Number 21750019
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Physical chemistry
Research InstitutionKyoto University

Principal Investigator

FUJIMOTO Kazuhiro  Kyoto University, 大学院・理学研究科, 研究員 (00511255)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords生物物理 / 量子化学 / 生物・生体工学 / 励起状態
Research Abstract

1. Color-tuning mechanism in Human red (HR), green (HG), and blue (HB) visual pigments was theoretically clarified in amino-acid level. The difference in absorption spectra between HR and HG could be explained in terms of direction of three hydroxyl residues in HR. 2. Mechanisms of color tuning in the M state of bacteriorhodopsin and in xanthorhodopsin were also investigated, which were compared with those in human visual pigments. 3. To analyze the mechanisms, new theoretical methods were developed.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (7 results) Remarks (2 results)

  • [Journal Article] Theoretical study of the opsin shift of deprotonated reti nal schiff base in the M state of bact eriorhodopsin2010

    • Author(s)
      Kazuhiro J.Fujimoto, Kota Asai, Jun-ya Hasegawa
    • Journal Title

      Physical Chemistry Chemical Physics : PCCP vol.12

      Pages: 13107-13116

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transition-density-fragment interaction approach for exciton-coupled circular dichroism spectra2010

    • Author(s)
      Kazuhiro J.Fujimoto
    • Journal Title

      The Journal of Chemical Physics vol.133

    • NAID

      120002619617

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Excited States of Fluorescent Proteins, mKO and DsRed : Chromophore-protein Electrostatic Interaction Behind the Color Variations2010

    • Author(s)
      Jun-ya Hasegawa, Takehiko Ise, Kazuhiro J.Fujimoto, Akihiro Kikuchi, EikoFukumura, Atsushi Miyawaki, Yoshitsugu Shiro
    • Journal Title

      Journal of Physical Chemistry B vol.114

      Pages: 2971-2979

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transition-density-fragment interaction approach for exciton-coupled circular dichroism spectra2010

    • Author(s)
      Kazuhiro J.Fujimoto
    • Journal Title

      The Journal of Chemical Physics

      Volume: 133

    • NAID

      120002619617

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Theoretical study of the opsin shift of deprotonated retinal schiff base in the M state of bacteriorhodopsin2010

    • Author(s)
      Kazuhiro J.Fujimoto, Kota Asai, Jun-ya Hasegawa
    • Journal Title

      Physical Chemistry Chemical Physics : PCCP

      Volume: 12 Pages: 13107-13116

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Excited States of Fluorescent Proteins, mKO and DsRed : Chromophore-protein Electrostatic Interaction Behind the Color Variations2010

    • Author(s)
      Jun-ya, Hasegawa, Takehiko Ise, Kazuhiro J.Fujimoto, Akihiro Kikuchi, Eiko Fukumura, Atsushi Miyawaki, Yoshitsugu Shiro
    • Journal Title

      Journal of Physical Chemistry B 114

      Pages: 2971-2979

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electronic Coulombic Coupling of Excitation-Energy Transfer in Xanthorhodopsin2009

    • Author(s)
      Kazuhiro J.Fujimoto, Shigehiko Hayashi
    • Journal Title

      Journal of the American Chemical Society vol.131

      Pages: 14152-14153

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Color Tuning Mechanism of Human Red, Green, and Blue Cone Pigments : SAC-CI Theoretical Study2009

    • Author(s)
      Kazuhiro Fujimoto, Jun-ya Hasegawa, Hiroshi Nakatsuji
    • Journal Title

      Bulletin of the Chemical Society of Japan vol.82

      Pages: 1140-1148

    • NAID

      10025321773

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electronic Coulombic Coupling of Excitation-Energy Transfer in Xanthorhodopsin2009

    • Author(s)
      Kazuhiro J.Fujimoto, Shigehiko Hayashi
    • Journal Title

      Journal of the American Chemical Society 131

      Pages: 14152-14153

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Color Tuning Mechanism of Human Red, Green, and Blue Cone Pigments : SAC-CI Theoretical Study2009

    • Author(s)
      Kazuhiro Fujimoto, Jun-ya Hasegawa, Hiroshi Nakatsuji
    • Journal Title

      Bulletin of the Chemical Society of Japan 82

      Pages: 1140-1148

    • NAID

      10025321773

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] エキシトンCDスペクトルに関する計算手法の開発とレチナールタンパク質への応用2010

    • Author(s)
      藤本和宏
    • Organizer
      第4回分子科学討論会
    • Place of Presentation
      大阪大学
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] レチナールタンパク質の吸収波長制御から何がわかるかタンパク質場やカロテノイド結合が何をもたらすか2010

    • Author(s)
      藤本和宏
    • Organizer
      分子研研究会「拡がるロドプシンの仲間から"何がわかるか""何をもたらすか"」
    • Place of Presentation
      分子科学研究所
    • Year and Date
      2010-03-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 生物による光吸収の多様性に関する電子論的起源2009

    • Author(s)
      藤本和宏
    • Organizer
      大阪大学蛋白質研究所セミナー「分子科学を基盤とした生命活動への理論的アプローチ」
    • Place of Presentation
      大阪大学
    • Year and Date
      2009-12-03
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Transition-Density-Fragment Interaction Approach for Excitation-Energy Transfer in Xanthorhodopsin2009

    • Author(s)
      Kazuhiro Fujimoto, Shigehiko Hayashi
    • Organizer
      第47回日本生物物理学会年会
    • Place of Presentation
      徳島文理大学
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] キサントロドプシンの励起エネルギー移動:遷移電子密度を用いた擬クーロン相互作用の計算法の開発2009

    • Author(s)
      藤本和宏、林重彦
    • Organizer
      第3回分子科学討論会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2009-09-23
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Transition-Density-Fragment Interaction Approach for Excitation-Energy Transfer in Xanthorhodopsin2009

    • Author(s)
      Kazuhiro Fujimoto, Shigehiko Hayashi
    • Organizer
      International Congress of Quantum Chemistry
    • Place of Presentation
      ヘルシンキ大学
    • Year and Date
      2009-06-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Transition-Density-Fragment Interaction Approach for Excitation-Energy Transfer in Xanthorhodopsin2009

    • Author(s)
      Kazuhiro Fujimoto, Shigehiko Hayashi
    • Organizer
      International Congress of Quantum Chemistry
    • Place of Presentation
      ヘルシンキ大学(フィンランド)
    • Year and Date
      2009-06-21
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://repository.kulib.kyoto-u.ac.jp/dspace

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/131807

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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