Synthesis of Heterocyclic Compounds via Decarbonylative Cycloadditions
| Project/Area Number |
21750040
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
KURAHASHI Takuya Kyoto University, 工学研究科, 助教 (50432365)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 複素環 / 触媒反応 / 遷移金属 / ニッケル / 環化付加反応 / 脱カルボニル |
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| Research Abstract |
The transition metal-catalyzed insertion reaction of an unsaturated carbon-carbon bond into a carbon-hetero atom bond of an heterocyclic compound is a useful transformation to prepare a more complicated heterocyclic compounds in a single step. However, there is no precedent for such a potentially valuable methodology. We postulated that oxidative addition of cyclic carbonyl compounds to nickel(0) and subsequent decarbonylation are facile and might allow insertion of alkynes. Thus, we developed the decarbonylative addition of anhydrides to alkynes using nickel(0) catalyst to form hetero cyclic compounds, which displays a wide range of biological activities.
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Report
(3 results)
Research Products
(45 results)
