Gene sensors based on "signal-on"-typed electrochemical sensingmethods
| Project/Area Number |
21750085
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Analytical chemistry
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
AOKI Hiroshi National Institute of Advanced Industrial Science and Technology, 環境管理技術研究部門, 主任研究員 (00392580)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 化学センサー / 電気化学 / バイオセンサ / DNA / 遺伝子検出 / 超分子電気化学 / 遺伝子プローブ / ラベル化不要 / シグナル・オン |
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| Research Abstract |
To promote high-sensitive gene detection methods with simplicity and rapidity, a novel "signal-on"-typed gene probe was developed based on dissociation of a redox complex triggered by DNA recognition. The probe enabled simple DNA detection for non-labeled DNAs with 5-fold increase in observed redox current. Moreover, gene sensing devices were developed to simultaneously detect multiple DNAs with simplicity, rapidity, and sequence-specificity.
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Report
(3 results)
Research Products
(48 results)
