| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Research Abstract |
The present study was conducted based on the development of chiral organo acid catalyst for enantioselective synthesis of homoallylamines. We successfully synthesized chiral phosphoric acid catalyst possessing pentafluorophenyl group for highly enantioselective Hosomi-Sakurai allylation reaction of imines with allyltrimethylsilanes. When the reaction was conducted with 3,5-di-tert-butyl benzoyl mine in the presence of 20 mol% chiral binaphtol derived phosphoric acid and 80mol% biphenol derived phosphoric acid, the homoallylamines were obtained in good yields with high enantioselectivites (90-99% ee).
|
