| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Addition of organometallic reagents to carbonyl compounds is one of the most important reactions in organic chemistry. In this study, we developed the activation of not only less reactive ketones but also organometallic reagents using highly active metal ate salt catalysts. Based on the activation of carbon-metal bond and the subsequent carbon-carbon bond forming reactions, we developed the highly efficient, practical tertiary alchol synthesis. Moreover, catalytic asymmetric tertiary alchol synthesis was established in the presence of chiral Zn(II)-ate catalysts.
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