Development of Iron-Catalyzed Cross-coupling Reactions by Controlling Coordination
| Project/Area Number |
21750098
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
HATAKEYAMA Takuji Kyoto University, 化学研究所, 助教 (90432319)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 触媒・化学プロセス / クロスカップリン / 鉄触媒 / クロスカップリング |
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| Research Abstract |
Development of iron-catalyzed cross-coupling reactions have been intensively explored but not established well. We have developed biaryl cross-coupling using iron fluoride-NHC carbene catalyst and alkyl-aryl coupling using iron chloride-TMEDA catalyst with the aid of coordination control. In this project, we have carried out a series of mechanistic studies to reveal iron (II)-(III) and (II)-(IV) mechanism starting from aryliron (II) species. Based on these mechanisms, novel iron (II) chloride-phenylenediphosphine complexes have been synthesized, which enable us to develop iron-catalyzed Suzuki-Miyaura coupling reaction.
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Report
(3 results)
Research Products
(28 results)
