| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
Borderline metal-catalyzed cycloisomerization of amino-allenes were investigated. In the reaction, we found that bismuth(III) triflate were more effective catalyst to proceed the reaction than other transition metal catalysts. The bismuth-catalyzed hydroamination can be applied to tandem ene-hydroamination of amino-allenes and amino-olefins with activated olefins and benzyl alcohols to provide multi-substituted N-heterocycles in good yields. In addition, we developed a cationic iron-catalyzed intramolecular hydroarylation of alkynes. In this reaction, the cationic iron catalyst promoted the addition of electron deficient arenes possessing strong electron-withdrawing group to alkynes, efficiently. This reactivity was very unique in comparison with other traditional catalysts for the similar hydroamination.
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