Control of monomer unit sequences and creation of high-order structures by dynamic reorganization of polymers with amino acid structures

• Project/Area Number: 21750117
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Polymer chemistry
• Research Institution: Yokohama National University
• Principal Investigator: OYAMA Toshiyuki Yokohama National University, 工学研究院, 准教授 (30313472)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 動的共有結合 / アミノ酸 / ポリペプチド / ジチオカルバメート / 結合組換え / 高次構造 / イミン / 円二色性スペクトル / 光刺激 / 結合組み換え / CDスペクトル

Research Abstract

Reaction of amino-acid-containing diamine monomers with carbon disulfide and the following polycondensation of the products with dihalide monomers afforded the corresponding polypeptide-like polymers with dithiocarbamate bonds in their main chains. Photo-irradiation to these polymers induced dynamic main-chain exchange through dithiocarbamates. Exchange reaction of imines introduced at side chains of poly(L-lysine) with low-molecular-weight aldehydes was also examined, and relatively fast imine-aldehyde exchange was observed.

Research Products

• [Presentation] Side-chain shuffling and higher-order structure modification of imine-functionalized poly(L-lysine) (2010)
  • Author(s): 大山俊幸(他3名)
  • Organizer: 2010環太平洋国際化学会議
  • Place of Presentation: ハワイコンベンションセンター(ホノルル,アメリカ合衆国)
  • Year and Date: 2010-12-17
• [Presentation] Side-chain shuffling and higher-order structure modification of imine-functionalized poly(L-lysine) (2010)
  • Author(s): 大由俊幸
  • Organizer: 2010環太平洋国際化学会議
  • Place of Presentation: ハワイコンベンションセンター(ホノルル、アメリカ合衆国)
  • Year and Date: 2010-12-17
• [Presentation] 側鎖にイミン結合を有するポリペプチドの合成と側鎖組み換え反応による高次構造変化 (2010)
  • Author(s): 大山俊幸(他3名)
  • Organizer: 第59回高分子討論会
  • Place of Presentation: 北海道大学高等教育機能開発総合センター(札幌市北区北17条西8丁目)
  • Year and Date: 2010-09-16
• [Presentation] Synthesis of imine-functionalized poly(L-lysine) and recombination reaction of the side chains (2009)
  • Author(s): 大山俊幸(他2名)
  • Organizer: 11th Pacific Polymer Conference
  • Place of Presentation: ケアンズコンベンションセンター(ケアンズ,オーストラリア)
  • Year and Date: 2009-12-08
• [Presentation] Synthesis of imine-functionalized poly (L-lysine) and recombination reaction of the side chaine (2009)
  • Author(s): 尾崎佑衣
  • Organizer: 11th Pacific Polymer Conference
  • Place of Presentation: Cairns Convention Center(ケアンズ、オーストラリア)
  • Year and Date: 2009-12-08
• [Presentation] イミン結合を導入したポリ(L-リシン)の合成と側鎖組み換え反応 (2009)
  • Author(s): 大山俊幸(他2名)
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学黒髪キャンパス(熊本市黒髪2丁目39番1号)
  • Year and Date: 2009-09-17
• [Presentation] イミン結合を導入したポリ(L-リシン)の合成と側鎖組み換え反応 (2009)
  • Author(s): 尾崎佑衣
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学黒髪キャンパス(熊本黒髪2丁目番1号)
  • Year and Date: 2009-09-17