Synthesis and properties of boron containing nucleobases analogues

Research Project

Project/Area Number	21750134
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Functional materials chemistry
Research Institution	The University of Tokyo
Principal Investigator	ITO Hiroshi The University of Tokyo, 大学院・理学研究科, 特任講師 (90506734)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	分子認識 / 人工核酸塩基 / ヘテロ環 / 含ホウ素化合物 / 蛍光プローブ / 人口核酸塩基
Research Abstract	As isoelectronic analogs of nucleobases, a series of BN-substituted nucleobases were synthesized and fully characterized. The crystallographic and spectroscopic analyses of B(6)-substituted 5-aza-6-borauracils (UBNs) and -thymines (TBNs) revealed that the framework and hydrogen-bonding pattern of the nucleobase analogues were similar to those of the original nucleobase. These "BN-nucleobases" are expected to be applied for novel photo-probes because they showed particular luminescence depended on the substitute on the boron atom.