Development of fluorescent probes-dendrimer conjugates and their application for cell and in vivo imaging
| Project/Area Number |
21750135
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional materials chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TERAI Takuya The University of Tokyo, 大学院・薬学系研究科, 助教 (00508145)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | センサー / 蛍光イメージング / デンドリマー / 蛍光 / イメージング / ケミカルバイオロジー / pHセンサー / 量子化学計算 |
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| Research Abstract |
In this study, we discovered that introduction of amino groups to BODIPY resulted in remarkable alternation of its absorption and fluorescence spectra, and based on this finding, succeeded in the development of several fluorescent probes. Furthermore, we synthesized conjugates of BDOIPYs and Frechet type dendrimers for fluorescence imaging applications. Also, we found that some luminescent lanthanide complexes with near-infrared emission could be introduced to live cells, depending on the structure of their antenna moiety.
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Hypoxia-sensitive Fluorescent Probes for in vivo Real-time Fluorescence Imaging of Acute Ischemia2010
Author(s)
Kazuki Kiyose, Kenjiro Hanaoka, Daihi Oushiki, Tomomi Nakamura, Mayumi Kajimura, Makoto Suematsu, Hiroaki Nishimatsu, Takehiro Yamane, Takuya Terai, Yasunobu Hirata, Tetsuo Nagano
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Journal Title
J.Am.Chem.Soc. 132
Pages: 15846-15848
Related Report
Peer Reviewed
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