Elucidation of anesthetic mechanism focused on the action to membrane interface
| Project/Area Number |
21750143
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional materials chemistry
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
YAMAMOTO Yasushi 名古屋工業大学, 大学院・工学研究科, 助教 (30335088)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 膜 / 集合体 / リン脂質単分子膜 / 膜溶液滴下法 / 顕微鏡観察 / 表面張力法 / 水平型QCM・QCI装置 / イソフルラン / 界面粘性変化 / 膜流動性 / 滴下法 / エンフルラン / 界面粘性増加 / 特異濃度点 |
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| Research Abstract |
We have investigated the morphology of phospholipid monolayer formed on the water surface by "dropping method" using surface tension measurement and optical microscope(Brewster angle microscope), and the interaction between the monolayer and anesthetic molecules using quartz crystal oscillator(QCO) method(quartz crystal microbalance(QCM) and quartz crystal impedance(QCI)). The QCO was attached horizontally to the monolayer on the water surface and we also focused on the resistance(corresponding to the interfacial viscosity) change on the QCI measurement. It is found that(1) the "dropping method" forms` fluidic' monolayer similar to membrane on the water surface compared to that by general compression method, and(2) the anesthetic molecules physisorb on the monolayer/water interface(QCM) and change(increase) in the interfacial viscosity of the interface(QCI). The anesthetic concentration dependence also showed the two-step change on both physisorption and viscosity. These results suggest that the "dropping method" is useful one for forming membrane-like monolayer on the water surface, and the condensation process of monolayer by the physisorption of anesthetic molecules concerns closely on the anesthetic phenomenon ; the condensation of membrane by anesthetic molecules decreases the membrane function
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Physisorption behavior of enflurane onthe dipalmitoyl phosphatidyl choline(DPPC) monolayer using high sensitive quartz crystal oscillator method2010
Author(s)
Y. Yamamoto, Z. Shervani, T. Shimoaki, T. Yokoyama, T. Ando, A. Somekawa, M. Takayama, K. Tamaoki, T. Yoshida, K. Taga, H. Kamaya, I. Ueda
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Journal Title
Colloids and Surfaces A : Physicochemical Engineering Aspects
Volume: 367
Pages: 47-51
Related Report
Peer Reviewed
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