Real-time measurements of supramolecular structural change of biological macromolecules in photoreaction
| Project/Area Number |
21750147
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional materials chemistry
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
YUASA Junpei Nara Institute of Science and Technology, 物質創成科学研究科, 助教 (00508054)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プローブ / DNA / 構造変化 / タンパク質 / 時間分解 / CPL / キラリティー / カルバゾール |
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| Research Abstract |
Circularly polarized luminescence (CPL) represents the differential emission of left and right circularly polarized light from a sample, being a reflection of the chirality of the excited fluorophore. This method has been used extensively to obtain structural information of biomolecules. In order to apply the CPL spectroscopic system to DNA, we will synthesize various luminescent probes for labeling biomolecules. Time-resolved CPL (TR-CPL) measurements of the fluorescence probes attached to biomolecules enable us to detect supramolecular structural changes of biological macromolecules in photoreaction. We have published 6 papers during this study duration.
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Report
(3 results)
Research Products
(59 results)
