| Project/Area Number |
21750163
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 生体認識 / 機能化学 / 超分子化学 / 生体材料 / 自己組織化 / 合成化学 |
|---|
| Research Abstract |
Spatial control of cell activities has been studied with photo-responsive hydro-gels in which photo-irradiated area turns into bio-active. Peptidic amphiphiles (PAs) including Arg-Gly-Asp sequence, an epitope to induce cell adhesion, with aphotocleavable protecting group has been used. In the case that glycine was protected, a PA performing solution to gel photo conversion, palmitoyl-V2E2RGDS, was obtained, where light-triggered cell adhesion with fixing cells in three-dimensional media by the photo-gelation.
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