Development of time-resolved circular dichroism measurement and its application to the detection of conformational dynamics in DNA-ligand complex
Project/Area Number |
21750164
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Chemistry related to living body
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Research Institution | Tohoku University |
Principal Investigator |
ARAKI Yasuyuki 東北大学, 多元物質科学研究所, 助教 (80361179)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | 生体機能関連化学 / 円二色性 / DNA / 色素 |
Research Abstract |
We aimed to develop the time-resolved circular dichroism measurement for the purpose of the detection of the dynamic behavior of this DNA-drug interactions, focusing on an entire chirality occurring as a result of DNA-drug interaction. We have successfully developed it and detected the dynamic behavior of DNA-drug interactions caused by the laser-induced conformational change of DNA-drug complexes.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Multiple photosynthetic reaction centres composed of supramolecular assemblies of zinc porphyrin dendrimers with a fullerene acceptor2011
Author(s)
Fukuzumi, S., Saito, K., Ohkubo, K., Kashiwagi, Y., Araki, Y., 他6名
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Journal Title
Chem. Commun.
Volume: 47
Pages: 7980-7982
Related Report
Peer Reviewed
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[Journal Article] Multiple photosynthetic reaction centres composed of supramolecular assemblies of zinc porphyrin dendrimers with a fullerene acceptor2011
Author(s)
Fukuzumi, S.; Saito, K.; Ohkubo, K.; Khoury, T.; Kashiwagi, Y.; Absalom, M.A.; Gadde, S.; D'Souza, F.; Araki, Y.; Ito, O.; Crossley, M.J.
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Journal Title
Chem.Commun.
Volume: 47
Pages: 7980-7982
Related Report
Peer Reviewed
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[Journal Article] Role of Phe113 at the distal side of the heme domain of an oxygen-sensor(Ec DOS)in the characterization of the heme environment2009
Author(s)
Ito, Shinya, Araki, Yasuyuki, Tanaka, Atsunari, Igarashi, Jotaro, Wada, Takehiko, Shimizu, Toru
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Journal Title
Journal of Inorganic Biochemistry 103
Pages: 989-996
Related Report
Peer Reviewed
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[Journal Article] Synthesis and Photophysical and Photovoltaic Properties of Porphyrin-Furan and-Thiophene Alternating Copolymers2009
Author(s)
Umeyama, Tomokazu, Takamatsu, Takeshi, Tezuka, Noriyasu, Matano, Yoshihiro, Araki, Yasuyuki, Wada, Takehiko, Yoshikawa, Osamu, Sagawa, Takashi, Yoshikawa, Susumu, Imahori, Hiroshi
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Journal Title
The Journal of Physical Chemistry C 113
Pages: 10798-10806
Related Report
Peer Reviewed
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