| Project/Area Number |
21750165
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemistry related to living body
|
|---|
| Research Institution | Yamagata University |
|---|
Principal Investigator |
HATANO Bunpei Yamagata University, 大学院・理工学研究科, 准教授 (20333990)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OGATA Tateaki 山形大学, 大学院・理工学研究科, 教授 (50091830)
KIJIMA Tatsuro 山形大学, 大学院・理工学研究科, 准教授 (50272084)
ITO Tomohiro 山形大学, 大学院・理工学研究科, 助教 (60361276)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
|
|---|
| Keywords | スピン剤 / 活性酸素種 / MC-PROXYL / 抗酸化酵素 / DMPO |
|---|
| Research Abstract |
We have achieved efficient syntheses of blood-brain-barrier permeable spin probe reagents, isoindole spin trap reagent bearing trifluoromethyl group, and chiral spin probe reagent based on DMPO. These spin reagents and their adducts gave strong and stable ESR signals, respectively.
|
