Research Project
Grant-in-Aid for Young Scientists (B)
I explored the effect of α-helical stabilization upon the binding of short peptides to DNAs. When a cross-linked peptide based on the homeodomain of transcription factor was titrated with a target DNA duplex, its dissociation constant (Kd) was calculated to be ca. 0.5 nM. This value was the double-digit smaller than that of the corresponding non-cross-linked peptide. The cross-linked peptide showed high substrate specificity for DNAs at the same level as the original DNA-binding protein.
All 2011 2010 2009 Other
All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (35 results) Remarks (4 results)
J.Am.Chem.Soc. 133巻
Pages: 656-659
J.Am.Chem.Soc.
Volume: 133 Pages: 656-659
Yakugaku Zasshi 130巻
Pages: 1283-1287
130000451670
Chem.-Eur.J. 16巻
Pages: 2401-2406
Yakugaku Zasshi
Volume: 130 Pages: 1283-1287
Chem.-Eur.J. 16
Tetrahedron 65巻
Pages: 9357-9361
Chem.Commun.
Pages: 7164-7166
Chem.Lett 38巻
Pages: 84-85
10023990667
Chem.Lett. 38
Tetrahedron 65
http://www.pha.u-toyama.ac.jp/yakka/index-j.html
http://jglobal.jst.go.jp/detail.php?JGLOBAL_ID=200901013658317736&t=1&d=1&q=1000370583