A search for peptides binding to assembly of amyloid-beta by novel fluorescence-screening
| Project/Area Number |
21750172
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Okayama University |
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Principal Investigator |
KITAMATSU Mizuki Okayama University, 大学院・自然科学研究科, 助教 (60379716)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ペプチド / 蛍光 / アミロイド / ペプチドライブラリー / アミロイドβ / 蛍光スペクトル / アミノ酸 / 蛍光アミノ酸 / アルツハイマー |
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| Research Abstract |
Many fluorescent dyes that fluoresces by exciting at light of various wavelength were connected to various peptides and these peptides were used as peptide library. These peptides were mixed with assembly of amyloid-beta in aqueous solution. Amyloid-beta is thought to be a causative agent of Alzheimer's disease. Of these fluorescent dye-modified peptides, the peptide bound to amyloid-beta strongly was found by fluorescence patterns of these fluorescent dyes modified to peptides.
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Report
(3 results)
Research Products
(9 results)
