Chemical model studies on the mechanism of dioxygen reduction and NO-inhibition of cytochrome c oxidase
| Project/Area Number |
21750173
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyushu University |
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Principal Investigator |
LIU Jin-Gang Kyushu University, 先導物質化学研究所, 特任准教授 (70380540)
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| Co-Investigator(Renkei-kenkyūsha) |
OHTA Takehiro 九州大学, 先導物質化学研究所, 助教 (70509950)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 酵素反応 / モデル化 / 分子認識 / シグナル伝達 / 生物無機化学 / 触媒・化学プロセス |
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| Research Abstract |
Cytochrome c oxidase (CcO), the terminal enzyme in the respiratory chain, catalyzes the 4e- reduction of O_2 to H_2O with high energy efficiency to supply the energy for life. This project is intended to probe the possible mechanisms of O_2-reduction in CcO as well as its reactivity with nitric oxide (NO) through chemical models. Using our delicate designed synthetic models, we have clarified the plausible roles of the cross-linked His-Tyr motif as observed in the active site of CcO ; we have generated and spectroscopically characterized important elusive intermediates species involved in the catalytic cycles of O_2-reduction as well as in the N-N bond formation of N2O. The spectroscopic investigation of those models has contributed further valuable insights into the mechanisms of O_2-reduction in CcO; the results obtained may lend merit suggestions for future design of molecular catalysts for O_2-reduction and NOx removing.
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Report
(3 results)
Research Products
(35 results)
