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Evaluation of mechanical field of cellular structure in stretched cell using real time in situ observation method

Research Project

Project/Area Number 21760081
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Materials/Mechanics of materials
Research InstitutionThe University of Tokushima

Principal Investigator

SATO Katsuya  The University of Tokushima, 大学院・ソシオテクノサイエンス研究部, 講師 (10403651)

Co-Investigator(Renkei-kenkyūsha) MINAMI Kazuyuki  山口大学, 大学院・理工学研究科, 教授 (00229759)
NAKASHIMA Yuta  山口大学, 大学院・理工学研究科, 助教 (70574341)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords生体力学 / 細胞力覚 / MEMS / メカノバイオロジー / 骨芽細胞 / 力学的刺激 / 細胞誘導 / 再生医療 / バイオメカニクス
Research Abstract

In this study, the aim is to evaluate mechanical field of cellular structure in stretched cell. We have developed novel cell stretching microdevice using MEMS technology. We proved the validity of our proposed structure design and fabrication process of the microdevice. We modified the washing process to improve bio-compatibility of the device. Finally, we demonstrated that our device enables to conduct in situ real time observation of stretched cell.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (12 results)

  • [Journal Article] Development of microstretching device to evaluate cell membrane strain field around sensing point of mechanical stimuli2010

    • Author(s)
      Katsuya SATO, Satoshi KAMADA, Kazuyuki MINAMI
    • Journal Title

      International Journal of Mechanical Sciences Vol.52, No.2

      Pages: 251-256

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of microstretching device to evaluate cell membrane strain field around sensing point of mechanical stimuli2010

    • Author(s)
      Katsuya Sato, Satoshi Kamada, Kazuyuki Minami
    • Journal Title

      International Journal of Mechanical Sciences 52

      Pages: 251-256

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高精度化細胞伸展マイクロデバイスの設計と試作2011

    • Author(s)
      門司亮, 南和幸, 中島雄太, 佐藤克也, 中野圭悟
    • Organizer
      日本機械学会中国四国支部第49期総会
    • Place of Presentation
      岡山理科大学
    • Year and Date
      2011-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 高精度化細胞伸展マイクロデバイスの設計と試作2011

    • Author(s)
      門司亮, 南和幸, 中島雄太, 佐藤克也
    • Organizer
      日本機械学会中国四国支部題49期総会・講演会
    • Place of Presentation
      岡山理科大学
    • Year and Date
      2011-03-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] ひずみ勾配場における細胞応答を観察するための細胞伸展デバイスの開発2011

    • Author(s)
      中野圭悟, 佐藤克也, 中島雄太, 南和幸
    • Organizer
      日本機械学会第23回バイオエンジニアリング講演会
    • Place of Presentation
      熊本大学
    • Year and Date
      2011-01-08
    • Related Report
      2010 Final Research Report
  • [Presentation] ひずみ勾配場における細胞応答を観察するための細胞伸展デバイスの開発2011

    • Author(s)
      中野圭吾, 佐藤克也, 中島雄太, 南和幸
    • Organizer
      日本機械学会第23回バイオエンジニアリング講演会
    • Place of Presentation
      熊本大学・黒髪キャンパス
    • Year and Date
      2011-01-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 基質牽引力に由来するアメーバ運動の極性形成機構2010

    • Author(s)
      岩楯好昭, 沖村千夏, 佐藤克也, 南和幸
    • Organizer
      日本生物物理学会第48回年会
    • Place of Presentation
      東北大学・川内北キャンパス
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Observation of initial calcium signal response to uniaxial stretching in a single osteoblastic cell using novel cell stretching microdevice2010

    • Author(s)
      Katsuya SATO, Kazuyuki MINAMI
    • Organizer
      6th World Congress of Biomechanics
    • Place of Presentation
      Singapore.
    • Year and Date
      2010-08-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Observation of initial calcium signal response to uniaxial stretching in osteoblastic cell using novel cell stretching microdevice2010

    • Author(s)
      Katsuya Sato, Kazuyuki Minami
    • Organizer
      6th World Congress on Biomechanics
    • Place of Presentation
      Singapore, Suntec convention
    • Year and Date
      2010-08-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 伸展刺激を受ける骨芽細胞応答のリアルタイムその場観察の試み2010

    • Author(s)
      鎌田慧, 佐藤克也, 南和幸
    • Organizer
      日本機械学会第22回バイオエンジニアリング講演会
    • Place of Presentation
      岡山理科大学
    • Year and Date
      2010-01-09
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 伸展刺激を受ける細胞のリアルタイム観察を可能にする細胞伸展MEMSデバイスの開発2009

    • Author(s)
      佐藤克也, 鎌田慧, 南和幸
    • Organizer
      日本機械学会 福祉工学シンポジウム2009
    • Place of Presentation
      高知工科大学
    • Year and Date
      2009-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 伸展刺激を受ける細胞のリアルタイム観察を可能にする細胞伸展MEMSデバイスの開発2009

    • Author(s)
      佐藤克也, 鎌田慧, 南和幸
    • Organizer
      日本機械学会福祉工学シンポジウム2009
    • Place of Presentation
      高知工科大学
    • Year and Date
      2009-09-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 伸展細胞のin situ観察を可能にする細胞伸展マイクロデバイスの開発2009

    • Author(s)
      佐藤克也, 鎌田慧, 南和幸
    • Organizer
      平成21年電気学会電子・情報・システム部門大会
    • Place of Presentation
      徳島大学
    • Year and Date
      2009-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 伸展細胞のin situ観察を可能にする細胞伸展マイクロデバイスの開発2009

    • Author(s)
      佐藤克也, 鎌田慧, 南和幸
    • Organizer
      電気学会電子・情報・システム部門大会
    • Place of Presentation
      徳島大学
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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