| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Neutrophils are the most abundant type of leukocytes. It is known that they adhere onto endothelial cells of venules and roll along the vessels slower than the whole blood. In fine capillaries whose inner diameter is smaller than the neutrophils, the cells could plug the vessels to cease blood flow. Therefore, it is essential to understand blood flow characteristics in microvasculature or behavior of neutrophils in immune response that clarifying interaction between the blood cells and the solid surfaces. In this research, we observed motion of HL60 cells, a kind of model cell of neutrophils, on a flat glass plate or cultured endothelial cells using the inclined centrifuge microscope to quantitatively evaluate adhesive characteristics of the blood cells on those solid surfaces.
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