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Development of multiscale analysis method for medical applications using microbubbles

Research Project

Project/Area Number 21760120
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Fluid engineering
Research InstitutionThe University of Tokyo

Principal Investigator

SUGIYAMA Kazuyasu  The University of Tokyo, 大学院・工学系研究科, 特任准教授 (50466786)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords数値流体力学 / 流体工学 / シミュレーション工学 / モデル化
Research Abstract

In consideration of lubricated, acoustic and thermal properties in microbubbly fluid systems, efficient numerical solvers for the flow motion have been equipped. A numerical algorithm was developed to capture the flexibility in the biomaterial/membrane. For the microbubble dynamics, insight into several behaviors such as a lift force in a shear flow, a deformation mode in an acoustic field and a heat source due to the volume oscillation was gained. The simulation method was applied to predicting a microbubble heat enhancement in an ultrasound field, and confirmed to qualitatively reproduce the measured relation between the heated region and the void fraction.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (31 results)

All 2011 2010 2009

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (15 results)

  • [Journal Article] A full Eulerian finite difference approach for solving fluid-structure coupling problems2011

    • Author(s)
      Sugiyama, K., Ii, S., Takeuchi, S., Takagi, S., Matsumoto, Y.
    • Journal Title

      Journal of Computational Physics Vol.230

      Pages: 596-627

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Particle-in-cell method for fluid-structure interaction simulations of neo-Hookean tube flows2011

    • Author(s)
      Sugiyama, K., Nagano, N., Takeuchi, S., Ii, S., Takagi, S., Matsumoto, Y.
    • Journal Title

      Theoretical and Applied Mechanics Japan Vol.59

      Pages: 245-256

    • NAID

      130004463774

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] An implicit full Eulerian method for the fluid-structure interaction problem2011

    • Author(s)
      Ii, S., Sugiyama, K., Takeuchi, S., Takagi, S., Matsumoto, Y.
    • Journal Title

      International Journal for Numerical Methods in Fluids Vol.65

      Pages: 150-165

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Numerical study on the shape oscillation of an encapsulated microbubble in ultrasound field2011

    • Author(s)
      Liu, Y.-Q., Sugiyama, K., Takagi, S., Matsumoto, Y.
    • Journal Title

      Physics of Fluids Vol.23

      Pages: 41904-41904

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Numerical study on the shape oscillation of an encapsulated microbubble in ultrasound field2011

    • Author(s)
      Liu, Y.-Q., Sugiyama, K., Takagi, S., Matsumoto, Y.
    • Journal Title

      Physics of Fluids

      Volume: 23(in press)(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Particle-in-cell method for fluid-structure interaction simulations of neo-Hookean tube flows2011

    • Author(s)
      Sugiyama, K., Nagano, N., Takeuchi, S., Ii, S., Takagi, S., Matsumoto, Y.
    • Journal Title

      Theoretical and Applied Mechanics Japan

      Volume: 59 Pages: 245-256

    • NAID

      130004463774

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A full Eulerian finite difference approach for solving fluid-structure coupling problems2011

    • Author(s)
      Sugiyama, K., Ii, S., Takeuchi, S., Takagi, S., Matsumoto, Y.
    • Journal Title

      Journal of Computational Physics

      Volume: 230 Pages: 596-627

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An implicit full Eulerian method for the fluid-structure interaction problem2011

    • Author(s)
      Ii, S., Sugiyama, K., Takeuchi, S., Takagi, S., Matsumoto, Y.
    • Journal Title

      International Journal for Numerical Methods in Fluids

      Volume: 65 Pages: 150-165

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Theoretical study on acoustic dynamics of circular liquid-gas micro-meniscus2010

    • Author(s)
      Sugiyama, K., Rathgen, H.
    • Journal Title

      Theoretical and Applied Mechanics Japan Vol.58

      Pages: 251-260

    • NAID

      130004463743

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Full Eulerian simulations of biconcave neo-Hookean particles in a Poiseuille flow2010

    • Author(s)
      Sugiyama, K., Ii, S., Takeuchi, S., Takagi, S., Matsumoto, Y.
    • Journal Title

      Computational Mechanics Vol.46

      Pages: 147-157

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Full-Eulerian finite-difference simulation of fluid flow in hyperelastic wavy channel2010

    • Author(s)
      Nagano, N., Sugiyama, K., Takeuchi, S., Ii, S., Takagi, S., Matsumoto, Y.
    • Journal Title

      Journal of Fluid Science and Technology Vol.5

      Pages: 475-490

    • NAID

      130000427049

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Full-Eulerian finite-difference simulation of fluid flow in hyperelastic wavy channel2010

    • Author(s)
      Nagano, N., Sugiyama, K, Takeuchi, S., Ii, S., Takagi, S., Matsumoto, Y.
    • Journal Title

      Journal of Fluid Science and Technology

      Volume: 5 Pages: 475-490

    • NAID

      130000427049

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Theoretical study on acoustic dynamics of circular liquid-gas micro-meniscus2010

    • Author(s)
      Sugiyama, K., Rathgen, H.
    • Journal Title

      Theoretical and Applied Mechanics Japan 58

      Pages: 251-260

    • NAID

      130004463743

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Full Eulerian simulations of biconcave neo-Hookean particles in a Poiseuille flow2010

    • Author(s)
      Sugiyama, K., Ii, S., Takeuchi, S., Takagi, S., Matsumoto, Y.
    • Journal Title

      Computational Mechanics 46

      Pages: 147-157

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 一様流中の円柱周りの減圧挙動に対する流れの剥離の影響2009

    • Author(s)
      杉山和靖
    • Journal Title

      日本機械学会論文集B 65巻

      Pages: 2361-2368

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 一様流中の円柱周りの減圧挙動に対する流れの剥離の影響2009

    • Author(s)
      杉山和靖
    • Journal Title

      日本機械学会論文集B 75

      Pages: 2361-2368

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 擬似圧縮性法に基づく完全オイラー型流体構造連成解析2011

    • Author(s)
      杉山和靖, 伊井仁志, 高木周, 松本洋一郎
    • Organizer
      生体力学シミュレーション研究
    • Place of Presentation
      理化学研究所,埼玉
    • Year and Date
      2011-03-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 固定メッシュ法に基づく流体構造連成シミュレーション2010

    • Author(s)
      杉山和靖, 伊井仁志, 竹内伸太郎, 高木周, 松本洋一郎
    • Organizer
      第24回数値流体力学シンポジウム
    • Place of Presentation
      慶應義塾大学日吉キャンパス,神奈川
    • Year and Date
      2010-12-20
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Deformation-induced lateral migration of a bubble slowly rising near a vertical plane wall2010

    • Author(s)
      Sugiyama, K., Takemura, F.
    • Organizer
      63rd Annual Meeting of the APS Division of Fluid Dynamics
    • Place of Presentation
      Long Beach, California, USA.
    • Year and Date
      2010-11-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Deformation-induced lateral migration of a bubble slowly rising near a vertical plane wall2010

    • Author(s)
      Sugiyama, K., Takemura, F.
    • Organizer
      63rd Annual Meeting of the APS Division of Fluid Dynamics
    • Place of Presentation
      Long Beach, California, USA
    • Year and Date
      2010-11-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Deformation-induced lift force on a bubble slowly rising near a vertical plane wall2010

    • Author(s)
      Sugiyama, K., Takemura, F.
    • Organizer
      8th Japan-UK Seminar on Multiphase Flows
    • Place of Presentation
      小樽,北海道
    • Year and Date
      2010-09-14
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 音場中の気液マイクロメニスカス界面の変形2010

    • Author(s)
      杉山和靖
    • Organizer
      日本流体力学会年会2010
    • Place of Presentation
      北海道大学,北海道
    • Year and Date
      2010-09-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 音場中の気液マイクロメニスカス界面の変形2010

    • Author(s)
      杉山和靖
    • Organizer
      日本流体力学会 年会2010
    • Place of Presentation
      北海道大学,北海道
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 壁面に沿う流れにおける超弾性体のオイラー型シミュレーション2010

    • Author(s)
      杉山和靖, 伊井仁志, 竹内伸太郎, 高木周, 松本洋一郎
    • Organizer
      日本機械学会年次大会
    • Place of Presentation
      名古屋工業大学,愛知
    • Year and Date
      2010-09-08
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 固定メッシュ法に基づくネオフック体管内流の流体構造連成シミュレーション2010

    • Author(s)
      杉山和靖, 長野直大, 竹内伸太郎, 伊井仁志, 高木周, 松本洋一郎
    • Organizer
      第59回理論応用力学講演会
    • Place of Presentation
      日本学術会議,東京
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] A full Eulerian finite difference approach for fluid-structure coupling problems2010

    • Author(s)
      Sugiyama, K., Ii, S., Takeuchi, S., Takagi, S., Matsumoto, Y.
    • Organizer
      International Conference on Multiphase Flow
    • Place of Presentation
      Tampa Bay, Florida, USA.
    • Year and Date
      2010-06-04
    • Related Report
      2010 Final Research Report
  • [Presentation] A full Eulerian finite difference approach for fluid-structure coupling problems2010

    • Author(s)
      Sugiyama, K., Ii, S., Takeuchi, S., Takagi, S., Matsumoto, Y
    • Organizer
      International Conference on Multiphase Flow
    • Place of Presentation
      Tampa Bay, Florida, USA
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 現配置参照型流体構造連成オイラー解析法2009

    • Author(s)
      杉山和靖, 竹内伸太郎, 伊井仁志, 高木周, 松本洋一郎
    • Organizer
      第23回数値流体力学シンポジウム
    • Place of Presentation
      東北大学,宮城
    • Year and Date
      2009-12-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 現配置参照型流体構造連成オイラー解析法2009

    • Author(s)
      杉山和靖, 竹内伸太郎, 伊井仁志, 高木周, 松本洋一郎
    • Organizer
      第23回数値流体力学シンポジウム
    • Place of Presentation
      東北大学
    • Year and Date
      2009-12-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 鉛直平板付近を上昇する変形気泡の揚力に対する潤滑効果2009

    • Author(s)
      杉山和靖, 竹村文男
    • Organizer
      日本流体力学会年会2009
    • Place of Presentation
      東洋大学,東京
    • Year and Date
      2009-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 鉛直平板付近を上昇する変形気泡の揚力に対する潤滑効果2009

    • Author(s)
      杉山和靖, 竹村文男
    • Organizer
      日本流体力学会年会2009
    • Place of Presentation
      東洋大学
    • Year and Date
      2009-09-02
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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