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Numerical Simulation of Biological Cell Behavior in Fluid Channel by Using Interface Capturing Method

Research Project

Project/Area Number 21760136
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Fluid engineering
Research InstitutionKeio University

Principal Investigator

FUKAGATA Koji  慶應義塾大学, 理工学部, 准教授 (80361517)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsバイオ流体力学 / 細胞 / 数値シミュレーション / マイクロ流路 / 弾性皮膜 / 粘弾性 / 実験 / Level Set法 / Phase Field法 / 流体工学 / 衡突モデル
Research Abstract

In this study, we aimed at developing a numerical simulation method that can handle fluid flows containing biological cells by extending the interface capturing methods used for numerical simulation of two-phase flows, which have light computational load. We developed a new method based on the combination of the Level Set Method and an isotropic elastic membrane model. In particular, we proposed a formulation utilizing the level set function to represent the displacement of the membrane in the Eulerian frame and its effectiveness was confirmed. In addition, to handle the collision of multiple cells, we proposed a repulsive force model utilizing the level set function and its effectiveness was also confirmed.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Analysis of cell accumulation mechanism in a rotational culture system2011

    • Author(s)
      K. Fukagata, K. S. Furukawa, and T. Ushida
    • Journal Title

      Journal of Mechanics in Medicine and Biology

      Volume: 11巻 Pages: 407-421

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of cell accumulation mechanism in a rotational culture system2011

    • Author(s)
      K.Fukagata, K.S.Furukawa, T.Ushida
    • Journal Title

      Journal of Mechanics in Medicine and Biology

      Volume: 11 Issue: 02 Pages: 407-421

    • DOI

      10.1142/s0219519410003745

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Level set法を用いた単純せん断下の二相界面挙動の数値シミュレーション2012

    • Author(s)
      橋本和卓, 深潟康二
    • Organizer
      日本機械学会関東学生会第51回学生員卒業研究発表講演会
    • Place of Presentation
      習志野
    • Year and Date
      2012-03-09
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 鉛直矩形管内における液相中の単一気泡および液滴の挙動2011

    • Author(s)
      矢内貴士, 田村秀一, 井上薫, 深潟康二
    • Organizer
      日本機械学会関東学生会第50回学生員卒業研究発表講演会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of membrane model by using Level-Set method2010

    • Author(s)
      S.Tamura, K.Fukagata
    • Organizer
      7th International Conference on Flow Dynamics
    • Place of Presentation
      仙台
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of membrane model by using Level-Set method2010

    • Author(s)
      S. Tamura and K. Fukagata
    • Organizer
      Proc. 7th Int. Conf. on Flow Dynamics
    • Place of Presentation
      Sendai
    • Related Report
      2011 Final Research Report
  • [Presentation] CIP-Level Set法を用いた細胞膜モデル計算手法の開発2010

    • Author(s)
      田村秀一, 深潟康二
    • Organizer
      第24回数値流体力学シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] CIP-Level Set法を用いたマイクロ流路中の細胞挙動の数値シミュレーション2009

    • Author(s)
      田村秀一, 横田理央, 深潟康二
    • Organizer
      第22回計算力学講演会
    • Place of Presentation
      金沢
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Book] 旋回培養による軟骨再生, 細胞療法・再生医療のための培養システム2010

    • Author(s)
      古川克子, 深潟康二, 牛田多加志
    • Publisher
      CMC出版
    • Related Report
      2011 Final Research Report
  • [Book] 細胞療法・再生医療のための培養システム(紀ノ岡・酒井編)2010

    • Author(s)
      古川克子, 深潟康二, 牛田多加志
    • Publisher
      CMC出版
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.fukagata.mech.keio.ac.jp

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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