Development and application of instrumental analysis method for detection of pharmaceuticals and metabolites in water environment

• Project/Area Number: 21760424
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Civil and environmental engineering
• Research Institution: National Institute of Public Health
• Principal Investigator: SIMAZAKI Dai National Institute of Public Health, 水道工学部, 室長 (60322046)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 医薬品 / 代謝物 / 機器分析 / 水環境

Research Abstract

Simultaneous instrumental analysis method for detection of three pharmaceuticals and five metabolites in water environment was successfully developed by using LC/MS/MS and served for an on-site investigation in the course of water purification and that of wastewater treatment. Seven pharmaceuticals and metabolites were found in the range of tens to thousands ng/L at a wastewater treatment plant. Both carbamazepine and its metabolite were found not only in raw water but also in finished water at a water purification plant, thus, they could possibly remain in drinking water.

Research Products

• [Journal Article] 水質試料中の医薬品と代謝物の同時分析法の開発と適用 (2010)
  • Author(s): 小野田優, 大久保豊, 島崎大, 秋葉道宏
  • Journal Title: 水環境学会誌 Volume: 33 Pages: 97-102
  • NAID: 130000307315
  • Peer Reviewed
• [Journal Article] 水質試料中の医薬品と代謝物の同時分析法の開発と適用
  • Author(s): 小野田優, 大久保豊, 島崎大, 秋葉道宏
  • Journal Title: 水環境学会誌 33(7) Pages: 97-102
  • NAID: 130000307315
  • Peer Reviewed
• [Presentation] 水道水源および水道水中における医薬品の存在実態 (2010)
  • Author(s): 島崎大, 国包章一
  • Organizer: 日本薬学会第130回年会衛生薬学シンポジウム(招待講演)
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-03-29
• [Presentation] Occurrence of Pharmaceuticals and Personal Care Products in Raw Water Used for the Drinking Water Supply in Japan (2009)
  • Author(s): T.Nishimura, R.Kubota, D.Simazaki, T.Suzuki, M.Akiba, S.Kunikane
  • Organizer: American Water Works Assosiation 2009 Water Quality Technology Conference and Exposition
  • Place of Presentation: シアトル(米国)
  • Year and Date: 2009-11-16
• [Presentation] Pharmaceuticals as possible contaminants in water environment-current situation in knowledge and gap (2009)
  • Author(s): D.Simazaki
  • Organizer: Seminar on environmental fate and impact of veterinary drugs
  • Place of Presentation: Korean National Veterinary Research & Quarantine Service, Anyang, Korea
  • Year and Date: 2009-11-04
• [Presentation] Pharmaceuticals as possible contaminants in water environment current situation in knowledge and gap (2009)
  • Author(s): Dai SIMAZAKI
  • Organizer: Seminar on environmental fate and impact of veterinary drugs (招待講演)
  • Place of Presentation: 韓国国立獣医科学検疫院
  • Year and Date: 2009-11-04
• [Presentation] Occurrence of Pharmaceuticals and Personal Care Products in Raw Water Used for the Drinking Water Supply in Japan (2009)
  • Author(s): T.Nishimura, R.Kubota, D.Simazaki, T.Suzuki, M.Akiba S.Kunikane
  • Organizer: AWWA 2009 Water Quality Technology Conference and Exposition
  • Place of Presentation: Seattle, USA
• [Presentation] 水道水源および水道水中における医薬品の存在実態,衛生薬学シンポジウム「水環境中の残留医薬品を考える-生態系への影響は?-」
  • Author(s): 島崎大, 国包章一
  • Organizer: 日本薬学会第130回年会要旨集,S40-3
  • Place of Presentation: 岡山