Development of porous metallic glass for biomedical application

• Project/Area Number: 21760544
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Structural/Functional materials
• Research Institution: Tohoku University
• Principal Investigator: WADA Takeshi 東北大学, 金属材料研究所, 助教 (10431602)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: バイオマテリアル / バルク金属ガラス / ポーラス金属 / ジルコニウム合金 / 生体材料

Research Abstract

The previously developed bulk metallic glasses (BMGs)with their critical glass-formation diameter exceeding 1 cm contain toxic elements such as Ni and Cu, which has restricted the application of BMGs as biomedical application. The present work has successfully prepared Cu and Ni-free Zr-based BMG with the critical glass formation diameter of about 2 cm. We have also developed a novel method of selective removal of toxic elements and simultaneous formation of porous structure on the surface of the BMGs by using dealloying phenomenon in the metallic melt.

Research Products

• [Journal Article] A Ni-and Cu-free Zr-based bulk metallic glass with excellent resistance to stress corrosion cracking in simulated body fluids (2012)
  • Author(s): A. Kawashima, T. Wada, et al.
  • Journal Title: Materials Science and Engineering A Volume: 30 Pages: 140-146
  • Peer Reviewed
• [Journal Article] A Ni- and Cu-Free Zr-Based Bulk Metallic Glass with Excellent Resistance to Stress Corrosion Cracking in Simulated Body Fluids (2012)
  • Author(s): A. Kawashima
  • Journal Title: Materials Science and Engineering A Volume: 542 Pages: 140-146
  • DOI: 10.1016/j.msea.2012.02.047
  • Peer Reviewed
• [Journal Article] Nano-to submicro-porous beta-Ti alloy prepared from dealloying in a metallic melt (2011)
  • Author(s): T. Wada, A D. Setyawan, et. al.
  • Journal Title: Scripta Materialia Volume: 65 Pages: 532-535
  • Peer Reviewed
• [Journal Article] Dealloying in metallic melt (2011)
  • Author(s): T. Wada, K. Yubuta, A. Inoue, H. Kato
  • Journal Title: Materials Letters Volume: 65 Pages: 1076-1078
  • Peer Reviewed
• [Journal Article] Nano- to submicro-porous beta-Ti alloy prepared from dealloying in a metallic melt (2011)
  • Author(s): T.Wada, A.D.Setyawan, et.al.
  • Journal Title: Scripta Materialia Volume: 65 Issue: 6 Pages: 532-535
  • DOI: 10.1016/j.scriptamat.2011.06.019
  • Peer Reviewed
• [Journal Article] ポーラス金属ガラスの作製と性質 (2010)
  • Author(s): 和田武、井上明久
  • Journal Title: 金属(アグネ技術センター) Volume: 80 Pages: 829-836
  • Peer Reviewed
• [Journal Article] ポーラス金属ガラスの作製と性質 (2010)
  • Author(s): 和田武
  • Journal Title: 金属 Volume: 80 Pages: 829-836
  • Peer Reviewed
• [Journal Article] Formation and Bioactivation of Zr-Al-Co Bulk Metallic Glasses (2009)
  • Author(s): T. Wada, F. Qin, et al.
  • Journal Title: Journal of Materials Research Volume: 24 Pages: 2941-2948
  • Peer Reviewed
• [Journal Article] Supercooled liquid foaming of a Zr-Al-Cu-Ag bulk metallic glass containing pressurized helium pores (2009)
  • Author(s): T. Wada, X. Wang, H. Kimura, A. Inoue
  • Journal Title: Materials Letters Volume: 63 Pages: 858-860
  • Peer Reviewed
• [Journal Article] Supercooled liquid foaming of a Zr-Al-Cu-Ag bulk metallic glass containing pressurized helium pores (2009)
  • Author(s): T.Wada
  • Journal Title: Materials Letters 63 Pages: 858-860
  • Peer Reviewed
• [Journal Article] Formation and Bioactivation of Zr-Al-Co Bulk Metallic Glasses (2009)
  • Author(s): T.Wada
  • Journal Title: Journal of Materials Research 24 Pages: 2941-2948
  • Peer Reviewed
• [Presentation] 金属溶湯デアロイング法によるナノポーラスチタン合金の作製 (2012)
  • Author(s): 和田武、アルベタス・デニ, 他2名
  • Organizer: 日本金属学会春季大会
  • Place of Presentation: 横浜
  • Year and Date: 2012-03-28
• [Presentation] 金属溶湯デアロイング法によるナノポーラスチタン合金の作製 (2012)
  • Author(s): 和田武、アルベタス・デニ, 他2名
  • Organizer: 日本金属学会春季大会
  • Place of Presentation: 横浜、日本
  • Year and Date: 2012-03-28
• [Presentation] 金属溶湯中で生じるデアロイング現象を利用したナノポーラス金属の創製 (2011)
  • Author(s): 和田武、湯葢邦夫、加藤秀実
  • Organizer: 日本金属学会秋季大会
  • Place of Presentation: 沖縄、日本
  • Year and Date: 2011-11-07
• [Presentation] New Dealloying Method for Developing Nanoporous Base Metals (2011)
  • Author(s): T. Wada M. Tsuda, et al.
  • Organizer: The 7th International Conference on Porous Metal and Metallic Foams
  • Place of Presentation: Korea
  • Year and Date: 2011-09-19
• [Presentation] 金属溶湯中で生じるデアロイング現象を利用したナノポーラス金属の創製 (2011)
  • Author(s): 和田武、湯葢邦夫、加藤秀実
  • Organizer: 日本金属学会秋季大会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-09-19
• [Presentation] New Dealloying Method for Developing Nanoporous Base Metals (2011)
  • Author(s): T.Wada, M.Tsuda, et.al.
  • Organizer: The 7^<th> International Conference on Porous Metal and Metallic Foams
  • Place of Presentation: Busan, Korea
  • Year and Date: 2011-09-19
• [Presentation] Preparation and Bioactivation of Zr-Al-Co Bulk Metallic Glasses (2009)
  • Author(s): T.Wada
  • Organizer: The 7^<th> International Conference on Bulk Metallic Glasses
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-11-02
• [Presentation] Zr-Al-Co基バルク金属ガラスの作製と性質 (2009)
  • Author(s): 和田武、秦風香, 他2名
  • Organizer: 日本金属学会秋季大会
  • Place of Presentation: 京都
  • Year and Date: 2009-09-15
• [Presentation] Preparation and Bioactivation of Zr-Al-Co Bulk Metallic Glasses (2009)
  • Author(s): T. Wada, F. Qin, et al.
  • Organizer: The 7th International Conference on Bulk Metallic Glasses
  • Place of Presentation: Korea
  • Year and Date: 2009-07-22
• [Book] マクロおよびナノポーラス金属の開発最前線, 第1章9ポーラス金属ガラスの作製と性質 (2011)
  • Author(s): 和田武
  • Publisher: シーエムシー出版
• [Patent(Industrial Property Rights)] Niを含む合金表面よりNiを除去する表面改質手法とその部材 (2010)
  • Inventor(s): 加藤秀実、和田武, 他
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Filing Date: 2010-10-22
  • Overseas
• [Patent(Industrial Property Rights)] Niを含む合金表面よりNiを除去する表面改質手法とその部材 (2010)
  • Inventor(s): 加藤秀実, 和田武, 他
  • Industrial Property Rights Holder: 東北大学
  • Filing Date: 2010-10-22
  • Overseas