| Project/Area Number |
21760558
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural/Functional materials
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| Research Institution | Osaka University |
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Principal Investigator |
ISHIMOTO Takuya Osaka University, 工学研究科, 助教 (50508835)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 骨質 / 生体アパタイト / 配向性 / 微小領域X線回折法 / 透過型光学系 / 骨力学機能 / 低侵襲化 / 生体アパタイト配向性 / 吸収係数 / ex vivo解析 / in vivo解析 |
|---|
| Research Abstract |
For extracted bones (ex vivo), quantitative analysis of the preferred orientation of biological apatite was successfully achieved by using a microbeam X-ray diffraction technique with a transmission optical system. The analytical condition was optimized based on the X-ray absorption coefficient of bone tissue and bone morphology. To expand this technique for in vivo (non-extracted) bone, X-ray absorption profile was taken for the detection of bone totally inside of soft tissues. By combining these techniques, it was possible to detect bone and obtain X-ray diffraction information from bone in vivo. This means the in vivo non-destructive and less-invasive method for analyzing bone quality was established in this study.
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