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Establishment of In Vivo Non-Destructive and Less-Invasive method for Analyzing Bone Quality

Research Project

Project/Area Number 21760558
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Structural/Functional materials
Research InstitutionOsaka University

Principal Investigator

ISHIMOTO Takuya  Osaka University, 工学研究科, 助教 (50508835)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords骨質 / 生体アパタイト / 配向性 / 微小領域X線回折法 / 透過型光学系 / 骨力学機能 / 低侵襲化 / 生体アパタイト配向性 / 吸収係数 / ex vivo解析 / in vivo解析
Research Abstract

For extracted bones (ex vivo), quantitative analysis of the preferred orientation of biological apatite was successfully achieved by using a microbeam X-ray diffraction technique with a transmission optical system. The analytical condition was optimized based on the X-ray absorption coefficient of bone tissue and bone morphology. To expand this technique for in vivo (non-extracted) bone, X-ray absorption profile was taken for the detection of bone totally inside of soft tissues. By combining these techniques, it was possible to detect bone and obtain X-ray diffraction information from bone in vivo. This means the in vivo non-destructive and less-invasive method for analyzing bone quality was established in this study.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (34 results)

All 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (21 results) Remarks (1 results)

  • [Journal Article] Biomechanical evaluation of regenerating long bone by nanoindentation, Journal of Materials Science2011

    • Author(s)
      T.Ishimoto, T.Nakano, M.Yamamoto Y.Tabata
    • Journal Title

      Materials in Medicine Vol.22[4]

      Pages: 969-976

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biomechanical evaluation of regenerating long bone by nanoindentation2011

    • Author(s)
      T.Ishimoto, T.Nakano, M.Yamamoto, Y.Tabata
    • Journal Title

      Journal of Materials Science : Materials in Medicine

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation and control of crystallographic alignment of biological apatite crystallites in bones2010

    • Author(s)
      T.Nakano, T.Ishimoto, J.-W.Lee, S.Miyabe, N.Ikeo H.Fukuda
    • Journal Title

      Materials Science Forum Vols.654-656

      Pages: 2212-2215

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of mechanical properties of regenerated bone by nanoindentation technique2010

    • Author(s)
      T.Ishimoto T.Nakano
    • Journal Title

      Materials Science Forum Vols.654-656

      Pages: 2220-2224

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Orientation of biological apatite in rat calvaria analyzed by microbeam X-ray diffractometer2010

    • Author(s)
      T.Ishimoto, T.Sakamoto T.Nakano
    • Journal Title

      Materials Science Forum Vols.638-642

      Pages: 576-581

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of mechanical properties of regenerated bone by nanoindentation technique2010

    • Author(s)
      T.Ishimoto, T.Nakano
    • Journal Title

      Materials Science Forum

      Volume: 654-656 Pages: 2220-2224

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation and control of crystallographic alignment of biological apatite crystallites in bones2010

    • Author(s)
      T.Nakano, T.Ishimoto, J.-W.Lee, S.Miyabe, N.Ikeo, H.Fukuda
    • Journal Title

      Materials Science Forum

      Volume: 654-656 Pages: 2241-2244

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orientation of biological apatite in rat calvaria analyzed by microbeam X-ray diffractometer2010

    • Author(s)
      T.Ishimoto, T.Sakamoto, T.Nakano
    • Journal Title

      Materials Science Forum 638-642

      Pages: 576-581

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis and formation mechanism of biological apatite (BAp) orientation in a growing rat skull model, Proceedings of PFAM18 (Processing and Fabrication of Advanced Materials2009

    • Author(s)
      T.Sakamoto, T.Ishimoto T.Nakano
    • Journal Title

      Edited by M.Niinomi, M.Morinaga, M. Nakai, N.Bhatnagar, T.S.Srivatsan)

      Pages: 1365-1372

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in bone microstructure and toughness during healing process of long bone2009

    • Author(s)
      T.Ishimoto, T.Nakano, Y.Umakoshi, Y.Tabata
    • Journal Title

      Journal of Physics : Conference Series 165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis and formation mechanism of biological apatite (BAp) orientation in a growing rat skull model2009

    • Author(s)
      T.Sakamoto, T.Ishimoto, T.Nakano
    • Journal Title

      Proceedings of PFAM 18

      Pages: 1365-1372

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anisotropic biological apatite orientation as a bone quality parameter in bone2009

    • Author(s)
      T.Nakano, T.Ishimoto, S.Miyabe, J.-W.Lee
    • Journal Title

      Proceedings of PFAM 18

      Pages: 1175-1184

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 頭蓋骨におけるアパタイト配向性の構築・再構築2011

    • Author(s)
      石本卓也, 阪本達志, 中野貴由
    • Organizer
      日本金属学会2011年春期(第148回)大会
    • Place of Presentation
      東京都世田谷区
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 頭蓋骨におけるアパタイト配向性の構築・再構築,2011

    • Author(s)
      石本卓也, 阪本達志, 中野貴由
    • Organizer
      日本金属学会2011年春期(第148回)大会
    • Place of Presentation
      東京都市大学,東京
    • Year and Date
      2011-03-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨成長および破骨細胞欠損にともなうマウス頭蓋骨の生体アパタイト配向性変化2011

    • Author(s)
      安食拓哉, 石本卓也, 中野貴由
    • Organizer
      日本金属学会2011年春期(第148回)大会
    • Place of Presentation
      東京都市大学,東京
    • Year and Date
      2011-03-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 頭蓋顔面インプラントの設計・開発のための頭蓋骨の骨微細構造解析2010

    • Author(s)
      阪本達志, 石本卓也, 中野貴由
    • Organizer
      (社)日本鉄鋼協会・(社)日本金属学会関西支部,材料開発研究会
    • Place of Presentation
      大阪大学吹田キャンパス,大阪
    • Year and Date
      2010-12-14
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス頭蓋骨の生体アパタイト配向性に及ぼすM-CSFの有無の影響2010

    • Author(s)
      安食拓哉, 阪本達志, 石本卓也, 李志旭, 中野貴由
    • Organizer
      日本金属学会2010年秋期(第147回)大会
    • Place of Presentation
      北海道大学,北海道
    • Year and Date
      2010-09-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 頭蓋骨における生体アパタイト配向化の部位依存性2010

    • Author(s)
      阪本達志, 石本卓也, 中野貴由
    • Organizer
      日本金属学会2010年秋期(第147回)大会
    • Place of Presentation
      北海道大学,北海道
    • Year and Date
      2010-09-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 頭蓋骨における生体アパタイト配向化の部位依存性2010

    • Author(s)
      阪本達志, 石本卓也, 中野貴由
    • Organizer
      日本金属学会2010年秋期(第147回)大会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス頭蓋骨の生体アパタイト配向性に及ぼすM-CSFの有無の影響2010

    • Author(s)
      安食拓哉, 阪本達志, 石本卓也, 李志旭, 中野貴由
    • Organizer
      日本金属学会2010年秋期(第147回)大会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 卵巣摘出ラットの骨再生過程における生体アパタイト配向化2010

    • Author(s)
      川原啓太, 李志旭, 石本卓也, 中野貴由
    • Organizer
      日本金属学会2010年秋期(第147回)大会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mechanical properties in regenerated bone evaluated by nanoindentation technique2010

    • Author(s)
      T.Ishimoto, T.Nakano
    • Organizer
      The 7^<th> Pacific Rim International Conference on Advanced Materials and Processing (PRICM-7)
    • Place of Presentation
      Cairns Convention Centre, Cairns, Australia
    • Year and Date
      2010-08-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Mechanical properties in regenerated bone evaluated by nanoindentation technique2010

    • Author(s)
      T.Ishimoto, T.Nakano
    • Organizer
      The 7^<th> Pacific Rim International Conference on Advanced Materials and Processing (PRICM-7)
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2010-08-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット頭蓋骨における骨成長にともなう生体アパタイト配向化2010

    • Author(s)
      石本卓也, 阪本達志, 中野貴由
    • Organizer
      第30回日本骨形態計測学会
    • Place of Presentation
      米子コンベンションセンターBIG SHIP,鳥取
    • Year and Date
      2010-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット頭蓋骨における骨成長にともなう生体アパタイト配向化2010

    • Author(s)
      石本卓也, 阪本達志, 中野貴由
    • Organizer
      第30回日本骨形態計測学会
    • Place of Presentation
      鳥取県米子市
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット頭蓋骨における生体アパタイト配向性形成メカニズム2010

    • Author(s)
      阪本達志, 石本卓也, 中野貴由
    • Organizer
      日本金属学会2010年春期(第146回)大会
    • Place of Presentation
      筑波大学,茨城
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 生体アパタイト配向性による再生骨の評価と力学機能との相関2010

    • Author(s)
      石本卓也, 中野貴由
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島国際会議場,広島
    • Year and Date
      2010-03-19
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Analysis and formation mechanism of biological apatite (BAp) orientation in a growing rat skull model2009

    • Author(s)
      T.Sakamoto, T.Ishimoto, T.Nakano
    • Organizer
      18th International Symposium on Processing and Fabrication of Advanced Materials (PFAM 18)
    • Place of Presentation
      Tohoku University, Sendai
    • Year and Date
      2009-12-13
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット頭蓋骨における生体アパタイト配向性形成過程の解析2009

    • Author(s)
      阪本達志, 石本卓也, 中野貴由
    • Organizer
      第31回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ,京都
    • Year and Date
      2009-11-16
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 骨成長にともなうラット頭蓋骨における生体アパタイト配向性変化2009

    • Author(s)
      石本卓也, 阪本達志, 中野貴由
    • Organizer
      日本金属学会,2009年秋期(第145回)大会
    • Place of Presentation
      京都大学,京都
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Orientation of biological apatite in rat calvaria analyzed by microbeam X-ray diffractometer2009

    • Author(s)
      T.Ishimoto, T.Sakamoto, T.Nakano
    • Organizer
      International Conference on Processing & Manufacturing of Advanced Materials (THERMEC'2009)
    • Place of Presentation
      Maritim Hotel Berlin, Berlin
    • Year and Date
      2009-08-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Orientation of Biological Apatite in Rat Calvaria Analyzed by Microbeam X-Ray Diffractometer2009

    • Author(s)
      T.Ishimoto, T.Sakamoto, T.Nakano
    • Organizer
      International Conference on PROCESSING & MANUFACTURING OF ADVANCED MATERIALS (THERMEC'2009)
    • Place of Presentation
      MARITIM Hotel Berlin, Berlin, Germany
    • Year and Date
      2009-08-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis and Formation Mechanism of Biological Apatite (BAp) Orientation in a Growing Rat Skull Model2009

    • Author(s)
      T.Sakamoto, T.Ishimoto, T.Nakano
    • Organizer
      18th International Symposium on PROCESSING AND FABRICATION OF ADVANCED MATERIALS (PFAM 18)
    • Place of Presentation
      Tohoku University, Sendai, Japan
    • Related Report
      2009 Annual Research Report
  • [Remarks] 阪本達志,石本卓也, 野貴由:平成22年度日本金属学会・鉄鋼協会関西支部材料開発研究会ポスターセッション研究発表優秀賞「頭蓋顔面インプラントの設計・開発のための頭蓋骨の骨微細構造解析」に対して,平成22年度日本金属学会・鉄鋼協会関西支部材料開発研究会,大阪大学吹田キャンパス,大阪,2011年12月14日.

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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