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Control of drug release from biodegradable microcapsules and development of self-degradable microcapsules based on membrane technology

Research Project

Project/Area Number 21760605
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Properties in chemical engineering process/Transfer operation/Unit operation
Research InstitutionThe University of Tokyo (2010)
Kogakuin University (2009)

Principal Investigator

AKAMATSU Kazuki  The University of Tokyo, 工学部, 助教 (50451795)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsマイクロカプセル / ミクロスフィア / 膜乳化 / SPG膜 / キトサン / 酵素 / 生分解性 / ドラッグデリバリーシステム / アルギン酸 / 単分散
Research Abstract

Microcapsules were prepared with alginate or chitosan, which are biocompatible polymers, by using the membrane emulsification technique. The detailed study on preparation condition enabled us to control the average diameter, monodispersity and the hollow structure of the microcapsules. Furthermore, a novel type of self-degradable microcapsules were successfully developed and demonstrated by encapsulating the enzymes that can decompose the shell polymers of the microcapsules.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (9 results) Remarks (1 results)

  • [Journal Article] Preparation of monodisperse chitosan microcapsules with hollow structures using the SPG membrane emulsification technique2010

    • Author(s)
      K.Akamatsu, W.Chen, Y.Suzuki, T.Ito, A.Nakao, T.Sugawara, R.Kikuchi, S.Nakao
    • Journal Title

      Langmuir Vol.26, No.18

      Pages: 14854-14860

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three Preparation Methods for Monodispersed Chitosan Microspheres Using the Shirasu Porous Glass Membrane Emulsification Technique and Mechanisms of Microsphere Formation2010

    • Author(s)
      K.Akamatsu, D.Kaneko, T.Sugawara, R.Kikuchi, S.Nakao
    • Journal Title

      Ind.Eng.Chem.Res. Vol.49, No.7

      Pages: 3236-3241

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of monodisperse chitosan microcapsules with hollow structures using the SPG membrane emulsification technique2010

    • Author(s)
      K.Akamatsu, et al
    • Journal Title

      Langmuir

      Volume: 26 Pages: 14854-14860

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 膜乳化法によるキトサンマイクロカプセルの合成と酵素封入法の開発2011

    • Author(s)
      池内悠人、赤松憲樹、中尾真一
    • Organizer
      第2回海水学会学生発表会
    • Place of Presentation
      秋田県立大学
    • Year and Date
      2011-03-06
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 膜乳化法による酵素封入キトサンマイクロカプセルの開発2011

    • Author(s)
      池内悠人、赤松憲樹、中尾真一
    • Organizer
      第13回化学工学会学生発表会
    • Place of Presentation
      秋田大学
    • Year and Date
      2011-03-05
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Preparation of monodispersed chitosan microcapsules with hollow structures using SPG membrane emulsification technique,2010

    • Author(s)
      K.Akamatsu, W.Chen, Y.Suzuki, T.Ito, A.Nakao, T.Sugawara, R.Kikuchi, S.Nakao
    • Organizer
      The 6^<th> conference of the Aseanian Membrane Society in conjunction with the 7^<th> International Membrane Science and Technology Conference (AMS6-IMSTEC10)
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2010-11-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Preparation of monodispersed chitosan microcapsules with hollow structures using SPG membrane emulsification technique2010

    • Author(s)
      K.Akamatsu, et al.
    • Organizer
      The 6^<th> conference of the Aseanian Membrane Society
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2010-11-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膜乳化法を用いたキトサン中空マイクロカプセルの合成と架橋法が中空構造に与える影響2010

    • Author(s)
      赤松憲樹、陳為、鈴木幸光、伊藤大知、菅原孝、菊地隆司、中尾真一
    • Organizer
      化学工学会第42回秋季大会
    • Place of Presentation
      同志社大学
    • Year and Date
      2010-09-06
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] SPG膜乳化法を用いた単分散中空キトサンマイクロカプセルの調製2010

    • Author(s)
      赤松憲樹、陳為、菅原孝、菊地隆司、中尾真一
    • Organizer
      日本膜学会第32年会
    • Place of Presentation
      産業技術総合研究所臨海副都心センター
    • Year and Date
      2010-05-13
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 膜乳化法を用いた中空型生分解性マイクロカプセルの合成2010

    • Author(s)
      陳為、赤松憲樹、菅原孝、菊地隆司、中尾真一
    • Organizer
      化学工学会第75年会
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2010-03-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Preparation of mono-dispersed chitosan microcapsules using SPG membrane emulsification technique2009

    • Author(s)
      K.Akamatsu, D.Kaneko, T.Sugawara, R.Kikuchi, S.Nakao
    • Organizer
      Euromembrane 2009 Conference
    • Place of Presentation
      Montpellier, France
    • Year and Date
      2009-09-09
    • Related Report
      2010 Final Research Report
  • [Presentation] SPG膜乳化法による単分散キトサンマイクロカプセルの合成と粒径制御2009

    • Author(s)
      兼子大作、赤松憲樹、菅原孝、菊地隆司、中尾真一
    • Organizer
      日本膜学会第31年会
    • Place of Presentation
      東京理科大学
    • Year and Date
      2009-05-21
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://er-web.sc.kogakuin.ac.jp/Profiles/9/0000826/profile.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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