Development of chemically-modified cellulose nanofibers for high-density adsorption of proteins and nanoparticles

• Project/Area Number: 21760613
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Properties in chemical engineering process/Transfer operation/Unit operation
• Research Institution: University of Miyazaki
• Principal Investigator: OSHIMA Tatsuya University of Miyazaki, 工学部, 准教授 (00343335)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: イオン交換 / セルロース / ナノファイバー / 吸着 / タンパク質 / ナノ粒子 / バクテリアセルロース / 固定化金属イオンアフィニティー

Research Abstract

Adsorbents prepared using cellulose nanofibers (CNFs) such as bacterial cellulose and microfibrillated cellulose would be beneficial for the adsorption of biomacromolecules and nanoparticles which are only adsorbed at surface adsorption sites. From the results of adsorption tests, chemically-modified CNSs bearing various functional groups exhibited higher adsorption capacities for biomacromolecules such as proteins.

Research Products

• [Journal Article] Phosphorylated bacterial cellulosefor adsorption of proteins (2011)
  • Author(s): T.Oshima, S.Taguchi, K.Ohe, Y.Baba
  • Journal Title: Carbohydr.Polym 83 Pages: 953-958
• [Journal Article] Phosphorylated Bacterial Cellulose for Adsorption of Proteins (2011)
  • Author(s): T.Oshima, S.Taguchi, K.Ohe, Y.Baba
  • Journal Title: Carbohydr.Polym. Volume: 83 Pages: 953-958
  • Peer Reviewed
• [Journal Article] Quaternaryammonium bacterial cellulose foradsorption of proteins (2010)
  • Author(s): T.Niide, H.Shiraki, T.Oshima, Y.Baba, N.Kamiya, M.Goto
  • Journal Title: Solv.Extr.Res.Dev.Jpn. 17 Pages: 73-81
• [Journal Article] Preparation ofiminodiacetic acid bacterialcellulose for immobilized metalaffinity chromatography (2010)
  • Author(s): T.Sakamoto, T.Oshima, S.Taguchi, K.Ohe, Y.Baba
  • Journal Title: J.IonExchange 21 Pages: 141-146
• [Journal Article] Quaternary ammonium bacterial cellulose for adsorption of proteins (2010)
  • Author(s): T.Niide, H.Shiraki, T.Oshima, Y.Baba, N.Kamiya, M.Goto
  • Journal Title: Solv.Extr.Res.Dev.Jpn Volume: 17 Pages: 73-81
  • Peer Reviewed
• [Journal Article] Preparation of Iminodiacetic Acid Bacterial Cellulose for Immobilized Metal Affinity Chromatography (2010)
  • Author(s): T.Sakamoto, T.Oshima, S.Taguchi, K.Ohe, Y.Baba
  • Journal Title: J.Ion Exchange Volume: 21 Pages: 141-146
  • Peer Reviewed
• [Presentation] Preparation ofiminodiacetic acid bacterialcellulose for immobilized metalaffinity chromatography (2010)
  • Author(s): T.Sakamoto, T.Oshima, S.Taguchi, K.Ohe, Y.Baba
  • Organizer: The 5thInternational Conference on IonExchange (ICIE'10)
• [Presentation] 銅(II)担持バクテリアセルロースを用いたタンパク質吸着特性の評価 (2010)
  • Author(s): 坂本俊彦、大島達也、大榮薫、馬場由成
  • Organizer: 化学工学会第42 回秋季大会
• [Presentation] 固定化金属アフィニティー吸着に適したバクテリアセルロース系吸着剤の開発 (2010)
  • Author(s): 坂本俊彦、田口幸子、大島達也、大榮薫、馬場由成
  • Organizer: 2010 年日本化学会西日本大会
• [Presentation] Preparation of Iminodiacetic Acid Bacterial Cellulose for Immobilized Metal Affinity Chromatography (2010)
  • Author(s): T.Sakamoto, T.Oshima, S.Taguchi, K.Ohe, Y.Baba
  • Organizer: The 5^<th> International Conference on Ion Exchange (ICIE'10)
  • Place of Presentation: メルボルン大学(オーストラリア)
• [Presentation] 銅(II)担持バクテリアセルロースを用いたタンパク質吸着特性の評価 (2010)
  • Author(s): 坂本俊彦、大島達也、大榮薫、馬場由成
  • Organizer: 化学工学会 第42回秋季大会
  • Place of Presentation: 広島大学(広島県)
• [Presentation] 固定化金属アフィニティー吸着に適したバクテリアセルロース系吸着剤の開発 (2010)
  • Author(s): 坂本俊彦、田口幸子、大島達也、大榮薫、馬場由成
  • Organizer: 2010年 日本化学会 西日本大会
  • Place of Presentation: 熊本大学(熊本県)
• [Presentation] Dominant factors for adsorptive recovery of carnosine based on immobilized metal affinity adsorption (2009)
  • Author(s): T.Oshima, T.Sakamoto, H.Tachiyama, K.Kanemaru, K.Ohe, Y.Baba
  • Organizer: Asia Pacific Biochemical Engineering Conference 2009 (APBioChEC APBioCHEC'09)
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2009-11-25
• [Presentation] Adsorptiverecovery of physiologically importantpeptides from fish resources based onmetal-affinity interaction (2009)
  • Author(s): T.Oshima, K.Ohe, Y.Baba
  • Organizer: XIXInternational Chemistry Seminar PalmOil and Sustainable Chemistry
  • Year and Date: 2009-05-20
• [Presentation] Adsorptive recovery of physiologically important peptides from fish resources based on metal-affinity interaction (2009)
  • Author(s): T.Oshima, K.Ohe, Y.Baba
  • Organizer: XIX International Chemistry Seminar Palm Oil and Sustainable Chemistry
  • Place of Presentation: ガジャマダ大学(ジョグジャカルタ、インドネシア)
  • Year and Date: 2009-05-20
• [Presentation] 銅(II)担持セルロース系キレート吸着剤におけるカルノシン類吸着特性の評価 (2009)
  • Author(s): 坂本俊彦、大島達也、大栄薫、馬場由成
  • Organizer: 化学工学会第41回秋季大会
• [Presentation] Dominantfactors for adsorptive recovery ofcarnosine based on immobilized metalaffinity adsorption (2009)
  • Author(s): T.Oshima, T.Sakamoto, H.Tachiyama,K.Kanemaru, K.Ohe, Y.Baba
  • Organizer: Asia PacificBiochemical Engineering Conference2009 (APBioChEC APBioChEC '09)