Research Project
Grant-in-Aid for Young Scientists (B)
We developed technologies that can transfer target proteins into cellular membrane and cytoplasm by enzymatically-specific modification of the C-terminal of target proteins with synthetic functional molecules. By the present technologies、target proteins could be modified with PEG-lipid on cellular membrane. This method realized that the efficiency in the phagocytosis of dendritic cells for cancer cells was successfully enhanced by introducing antibodies onto cancer membranes. In addition、we developed a method that can easily transfer target proteins to cytoplasm by attaching cell-penetrating peptide bearing the dye、which generates radical under photo-irradiation、to target protein and irradiating light after cellular uptake of the present modified protein.
All 2011 2010 2009
All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (11 results)
Appl.Biochem.Biotechnol. 164
Pages: 957-967
J.Biosci.Bioeng. 111
Pages: 10-15
110008440340
J.Biosci.Bioeng.
Volume: 111 Pages: 10-15
Appl.Biochem.Biotechnol.
Volume: (印刷中(掲載確定))
