GenomeevoIutioncausedbygenedupIication

• Project/Area Number: 21770003
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Genetics/Genome dynamics
• Research Institution: Kyushu University (2010-2011); The Graduate University for Advanced Studies (2009)
• Principal Investigator: TESHIMA Kosuke 九州大学, 理学研究院, 学術研究員 (20447593)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: ゲノム進化 / 自然選択 / 遺伝子変換 / 遺伝子重複 / 集団遺伝学 / 遺伝子系図 / 適応進化 / 機能獲得 / Coalescent simulation / coalescent simulation / シミュレーション / 遺伝的変異

Research Abstract

Gene duplication is one of the most important factors that contribute to genome evolution. Researches on gene duplication and neofunctionalization will improve our understanding of biological evolution. In this project, I conducted theoretical population genetics research and genome data analysis to understand the evolutionary mechanism of gene duplication. Extensive simulation study revealed the detailed pattern of nucleotide diversity within and flanking regions of gene duplication. One of the unexpected results obtained from this project is that the signature of natural selection is more likely to be preserved in the flanking region rather than within duplicates. Simulation programs developed in this project and the results of this project will contribute to further genome data analysis.

Research Products

• [Journal Article] Innan, The coalescent with selection on copy number variants (2012)
  • Author(s): Teshima KM and H.
  • Journal Title: Genetics Volume: vol.190 Pages: 1077-1086
  • Peer Reviewed
• [Journal Article] The coalescent with selection on copy number variants (2012)
  • Author(s): KM. Teshima, H.Innan
  • Journal Title: Genetics Volume: 190 Issue: 3 Pages: 1077-1086
  • DOI: 10.1534/genetics.111.135343
  • Peer Reviewed
• [Journal Article] modifying Hudson' s ins software to generate samples of D NA sequences with a biallelic site under selection (2009)
  • Author(s): Teshima KM, mbs
  • Journal Title: BMC Bioinformatics Pages: 166-166
  • Peer Reviewed
• [Journal Article] Variations in Hd1 proteins, Hd3a promoters, and Ehdl expression levels contribute to diversity of flowering time in cultivated rice. Proc (2009)
  • Author(s): Takahashi Y, Teshima KM, Yokoi S, Innan H, Shimamoto K
  • Journal Title: Natl. Acad. Sci. USA Volume: vol.106 Pages: 4555-4560
  • Peer Reviewed
• [Journal Article] mbs : modifying Hudson's ms software to generate samples of DNA sequences with a biallelic site under selection. (2009)
  • Author(s): Teshima KM
  • Journal Title: BMC Bioinformatics 10 Pages: 166-166
  • Peer Reviewed
• [Journal Article] Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of flowering time in cultivated rice. (2009)
  • Author(s): Takahashi Y
  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 4555-4560
  • Peer Reviewed
• [Presentation] 重複遺伝子とその周辺領域の遺伝的変異に関する研究 (2010)
  • Author(s): 手島康介
  • Organizer: 日本遺伝学会第82回大会
  • Place of Presentation: 北海道大学
  • Year and Date: 2010-09-22
• [Presentation] 重複遺伝子とその周辺領域の遺伝的変異に関する研究 (2010)
  • Author(s): 手島康介
  • Organizer: 日本遺伝学会
  • Place of Presentation: 北海道大学
  • Year and Date: 2010-09-22
• [Presentation] 遺伝子重複の進化における遺伝子変換の影響 (2010)
  • Author(s): 手島康介
  • Organizer: 日本進化学会第12回大会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2010-08-04
• [Presentation] 遺伝子重複の進化における遺伝子変換の影響 (2010)
  • Author(s): 手島康介
  • Organizer: 日本進化学会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2010-08-04
• [Presentation] 自然選択の影響をうけたDNA配列を生成するCoalescentシミュレーションプログラムの開発 (2009)
  • Author(s): 手島康介
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 信州大学
  • Year and Date: 2009-09-18
• [Presentation] 自然選択の影響をうけたDNA配列を生成するCoalescentシミュレーションプエログラムの開発 (2009)
  • Author(s): 手島康介
  • Organizer: 日本遺伝学会
  • Place of Presentation: 信州大学理学部
  • Year and Date: 2009-09-18
• [Remarks]
  • URL: http://www.sendou.sokenn.ac.jp/esb/innan/InnanLab/
• [Remarks]
  • URL: http://www.sendou.soken.ac.jp/esb/innan/InnanLab/