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Do clock neurons work as a timekeeper for emergence of behavior?

Research Project

Project/Area Number 21770074
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Animal physiology/Animal behavior
Research InstitutionTohoku University

Principal Investigator

KOGANEZAWA Masayuki  東北大学, 大学院・生命科学研究科, 准教授 (10302085)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsショウジョウバエ / 時計遺伝子 / 求愛行動 / 脳・神経 / 時計ニューロン / 行動発現 / スケールフリー
Research Abstract

Activity of animals shows 24 hr rhythmicity called the circadian rhythm. This rhythm is controlled by the function of clock neurons and clock genes expressed in these neurons. The question is that the clock genes and the clock neurons also regulate an emergence of behavior in shorter time scale. By using Drosophila, I shown in this study that the clock genes affect on the emergence of behavior in shorter time scale, such as the locomotion activity or the courtship behavior.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (55 results)

All 2012 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (43 results)

  • [Journal Article] An untranslated RNA sequence encoded in the putative regulatory regionof fruitless, a major courtship regulator gene of Drosophila2012

    • Author(s)
      Takayanagi S, Toba G, Koganezawa M, Lukacsovich T, Yamamoto D
    • Journal Title

      Intern.J.Biol

      Volume: 4 Issue: 1 Pages: 20-26

    • DOI

      10.5539/ijb.v4n1p20

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 同定介在ニューロンP1の強制活性化による雄の性行動の解発とP1のフェロモン応答性2011

    • Author(s)
      古波津創, 小金澤雅之, 山元大輔
    • Journal Title

      Aroma Research

      Volume: 46 Pages: 139-139

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Female contact activates male-specific interneurons that trigger stereotypic courtship behavior in a Drosophila male2011

    • Author(s)
      Kohatsu, S., Koganezawa, M. Yamamoto, D.
    • Journal Title

      Neuron

      Volume: 69 Pages: 498-208

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Female contact activates male-specific interneurons that trigger stereotypic courtship behavior in a Drosophila male.2011

    • Author(s)
      Kohatsu, S., Koganezawa, M., Yamamoto, D.
    • Journal Title

      Neuron

      Volume: 69 Pages: 498-508

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sexually dimorphic shaping of interneuron dendrites involves the Hunchback transcription factor.2011

    • Author(s)
      Goto, J., Mikawa, Y., Koganezawa, M., Ito, H., Yamamoto, D.
    • Journal Title

      J.Neurosci.

      Volume: 31 Pages: 5454-5459

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gr39a, highly deversified gustatory receptor in Drosophila, has a role in sexual behavior.2011

    • Author(s)
      Watanabe, K., Toba, G., Koganezawa, M., Yamamoto, D.
    • Journal Title

      Behav.Genet.

      Volume: (EPub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The shaping of male courtship posture by lateralized gustatory inputs to male-specific interneurons2010

    • Author(s)
      Koganezawa, M., Haba, D., Matsuo, T. and Yamamoto, D.
    • Journal Title

      Curr. Biol.

      Volume: 20 Pages: 1-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal synaptic outputs determine the sexual fate of postsynaptic targets.2010

    • Author(s)
      Nojima, T., Kimura, K-I., Koganezawa, M., Yamamoto, D.
    • Journal Title

      Curr.Biol.

      Volume: 20 Pages: 836-840

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phenotypic interactions of spinster with the genes encoding proteins for cell death control in Drosophila melanogaster2010

    • Author(s)
      Sakurai, A., Nakano, Y., Koganezawa, M., Yamamoto, D.
    • Journal Title

      Arch.Insect.Biolchem.Physiol. 73

      Pages: 119-127

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The shaping of male courtship posture by lateralized gustatory inputs to male-specific interneurons2010

    • Author(s)
      Koganezawa, M., Haba, D., Matsuo, T., Yamamoto, D.
    • Journal Title

      Curr.Biol. 20

      Pages: 1-8

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Memory effects on scale-free dynamics in foraging Drosophila2009

    • Author(s)
      Koganezawa, M., Hara, H., Hayakawa, Y., Shimada, I.
    • Journal Title

      J. Theor. Biol.

      Volume: 260 Pages: 353-358

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Memory effects on scale-free dynamics in foraging Drosophila2009

    • Author(s)
      Koganezawa, M., Hara, H., Hayakawa, Y., Shimada, I.
    • Journal Title

      J.Theor.Biol. 260

      Pages: 353-358

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] longitudinals lacking cooperates with fruitless in generating sexual differences in neuronal structures and behavior2012

    • Author(s)
      Sato K, Toba G, Ito H, Koganezawa M, Yamamoto D
    • Organizer
      53rd Drosophila Annual Conference
    • Place of Presentation
      Sheraton Chicago Hotel & Towers. Chicago, U.S.A.
    • Related Report
      2011 Annual Research Report
  • [Presentation] ショウジョウバエ求愛歌のパターンを決める司令ニューロン2011

    • Author(s)
      小金澤雅之, 山元大輔
    • Organizer
      平成23年度日本動物学会東北支部大会
    • Place of Presentation
      弘前大学農学生命科学部
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] ショウジョウバエの求愛行動の神経基盤2011

    • Author(s)
      小金澤雅之
    • Organizer
      基生研シンポジウム「配偶行動の分子神経基盤:実験動物の研究から」ヒトの恋愛感情はどこまで理解できるのか?」
    • Place of Presentation
      岡崎コンファレンスセンター
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional dissection of the neural circuitry involving in male courtship behavior of Drosophila.2011

    • Author(s)
      Koganezawa, M.
    • Organizer
      The 2nd UCL-Tohoku University Symposium
    • Place of Presentation
      東北大学
    • Year and Date
      2011-01-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] ショウジョウバエ求愛行動を解発するfruitless発現神経回路2011

    • Author(s)
      小金澤雅之、山元大輔
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川
    • Related Report
      2011 Final Research Report
  • [Presentation] Male courtship behavior triggered by the artificial activation of doublesex-expressing neurons2011

    • Author(s)
      Koganezawa, M. and Yamamoto, D.
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Animal behavior as a complex adaptive system. 8th International Congress of Comparative2011

    • Author(s)
      Shimada, I. and Koganezawa, M.
    • Organizer
      Physiology and Biochemistry
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] The neural circuitry contributing to male courtship behavior of Drosophila. 8th International Congress of Comparative2011

    • Author(s)
      Koganezawa, M.
    • Organizer
      Physiology and Biochemistry
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] The neural circuitry contributing to male courtship behavior of Drosophila2011

    • Author(s)
      Koganezawa, M
    • Organizer
      8th International Congress of Comparative Physiology and Biochemistry
    • Place of Presentation
      Nagoya Congress Center
    • Related Report
      2011 Annual Research Report
  • [Presentation] Animal behavior as a complex adaptive system2011

    • Author(s)
      Shimada, I., Koganezawa, M.
    • Organizer
      8th International Congress of Comparative Physiology and Biochemistry
    • Place of Presentation
      Nagoya Congress Center
    • Related Report
      2011 Annual Research Report
  • [Presentation] Male courtship behavior triggered by the artificial activation of doublesex-expressing neurons2011

    • Author(s)
      Koganezawa M, Yamamoto D
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identifying subsets of brain neurons that affect female sexual receptivity in Drosophila2011

    • Author(s)
      Sakurai A, Koganezawa M, Yamamoto D
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] fruitless and longitudinals lacking cooperate to generate the brain sexual differences that govern male courtship behavior in Drosophila2011

    • Author(s)
      Sato K, Toba G, Koganezawa M, Yamamoto D
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] ショウジョウバエ求愛行動を解発するfruitless発現神経回路2011

    • Author(s)
      小金澤雅之, 山元大輔
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川市大雪クリスタルホール
    • Related Report
      2011 Annual Research Report
  • [Presentation] ショウジョウバエ成虫脳における性決定因子doublesex発現ニューロン群に見られる性差2011

    • Author(s)
      木村賢一, 小金澤雅之, 佐藤千晶, 山元大輔
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川市大雪クリスタルホール
    • Related Report
      2011 Annual Research Report
  • [Presentation] Subsets of brain neurons required for fully acquiring sexual receptivity in females as determined by behavioral MARCM for spinster gene functions2011

    • Author(s)
      Sakurai A, Koganezawa M, Yamamoto D
    • Organizer
      2011 Neurobiology of Drosophila meeting
    • Place of Presentation
      Cold Spring Harbor LaboratoryNew York, U.S.A.
    • Related Report
      2011 Annual Research Report
  • [Presentation] fruitless and longitudinals lacking cooperate to generate the sexual differences of the brain and courtship behavior of Drosophila.2011

    • Author(s)
      Sato, K., Koganezawa, M., Toba, G., Yamamoto, D.
    • Organizer
      The 1st Tohoku International Symposium on multidisciplinary Neuroscience.
    • Place of Presentation
      東北大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] fruitless and longitudinals lacking cooperate to generate the sexual differences of the brain and courtship behavior of Drosophila.2010

    • Author(s)
      Sato, K., Koganezawa, M., Toba, G., Yamamoto, D.
    • Organizer
      東北大学脳科学GCOE第31回若手フォーラム
    • Place of Presentation
      東北大学
    • Year and Date
      2010-12-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] fruitless and longitudinals lacking cooperate to generate the sexual differences of the brain and courtship behavior of Drosophila2010

    • Author(s)
      Sato, K., Koganezawa, M., Toba, G., Yamamoto, D.
    • Organizer
      東北大学脳科学GCOE第29回若手フォーラム
    • Place of Presentation
      東北大学
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] ショウジョウバエ求愛行動を制御する司令ニューロンの同定2010

    • Author(s)
      小金澤雅之, 山元大輔
    • Organizer
      日本動物学会東北支部大会
    • Place of Presentation
      福島県立医科大学・光が丘会館(福島)
    • Year and Date
      2010-08-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional dissection of the neural circuitry triggering courtship behavior of Drosophila2010

    • Author(s)
      Koganezawa, M.
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional dissection of the neural circuitry triggering courtship behavior of Drosophila.ショウジョウバエ求愛行動をトリガーする神経回路の機能解剖2010

    • Author(s)
      Koganezawa, M.
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      いわて県民情報交流センター
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Male courtship behavior triggered by the artificial activation of fruitless-expressing neurons2010

    • Author(s)
      Koganezawa, M. and Yamamoto, D.
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] Neural masculinization in the Drosophila brain is controlled by the recruitment of chromatin regulators Rpd3 or HP1 to a Fruitless-containing protein complex.2010

    • Author(s)
      Ito, H., Koganezawa, M., Ote, M., Matsumoto, K., Hama, C., Yamamoto, D.
    • Organizer
      51st Annual Drosophila Research Conference
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chromatin regulators control neural masculinization in the Drosophila brain.2010

    • Author(s)
      Ito, H., Koganezawa, M., Ote, M., Matsumoto, K., Hama, C., Yamamoto, D.
    • Organizer
      Tohoku University Global Brain Science 2010 Summer Retreat
    • Place of Presentation
      東北大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neuronal synaptic outputs determine the sexual fate of postsynaptic targets.2010

    • Author(s)
      Nojima, T., Kimura, K., Koganezawa, M., Yamamoto, D.
    • Organizer
      13th European Drosophila Neurobiology Conference "Neurofly 2010"
    • Place of Presentation
      Manchester, UK
    • Related Report
      2010 Annual Research Report
  • [Presentation] Male courtship behavior triggered by the artificial activation of fruitless-expressing neurons.2010

    • Author(s)
      Koganezawa, M., Yamamoto, D.
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sexually dimorphic development of fruitless-expressing neurons requires longitudinals lacking function.2010

    • Author(s)
      Sato, K., Koganezawa, M., Toba, G., Yamamoto, D.
    • Organizer
      RNAフロンティアミーティング2010
    • Place of Presentation
      静岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chromatin regulators control neural masculinization in Drosophila.2010

    • Author(s)
      Ito, H., Koganezawa, M., Ote, M., Matsumoto, K., Hama, C., Yamamoto, D.
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neuronal synaptic outputs determine the sexual fate of postsynaptic targets.2010

    • Author(s)
      Nojima, T., Kimura, K., Koganezawa, M., Yamamoto, D
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] fruitless and longitudinals lacking cooperate to generate the sexual differences of the brain and courtship behavior of Drosophila.2010

    • Author(s)
      Sato, K., Koganezawa, M., Toba, G., Yamamoto, D.
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] 接触フェロモン受容によるショウジョウバエ求愛行動の制御2009

    • Author(s)
      小金澤雅之, 山元大輔
    • Organizer
      平成21年度日本動物学会東北支部会
    • Place of Presentation
      宮城教育大学, 仙台
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pheromonal signal shapes courtship song of Drosophila2009

    • Author(s)
      Koganezawa, M. and Yamamoto, D.
    • Organizer
      The 7th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional dissection of the neural circuitry controlling male courtship by the manipulation of single neuron activities2009

    • Author(s)
      Koganezawa, M. and Yamamoto, D
    • Organizer
      Janelia Farm Conference : Improving the Toolkit for Drosophila Neurogenetics
    • Place of Presentation
      Washington(USA)
    • Related Report
      2011 Final Research Report
  • [Presentation] Sexually dimorphic fruitless-expressing interneurons shape male courtship posture in Drosophila2009

    • Author(s)
      Koganezawa, M. and Yamamoto, D.
    • Organizer
      The 32nd Annual Meeting the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] フェロモン受容体Gr32a発現ニューロンはショウジョウバエの求愛行動の制御に関与する2009

    • Author(s)
      小金澤雅之、山元大輔
    • Organizer
      日本味と匂学会第43回大会
    • Place of Presentation
      旭川
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Recruitment of chromatin regulators Rpd3 and HP1 to fruitless-containing complex controls neural masculinization in Drosophila2009

    • Author(s)
      Ito, H., Koganezawa, M., Ote, M., Matsumoto, K., Hama, C., Yamamoto, D.
    • Organizer
      The 32^<nd> Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Pacifico Yokohama
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pheromonal signal shapes courtship song of Drosophila2009

    • Author(s)
      小金澤雅之, 山元大輔
    • Organizer
      The 7^<th> International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
    • Place of Presentation
      Fukuoka
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional dissection of the neural circuitry controlling male courtship by the manipulation of single neuron activities2009

    • Author(s)
      小金澤雅之, 山元大輔
    • Organizer
      Janelia Farm Conference : Improving the Toolkit for Drosophila Neurogenetics
    • Place of Presentation
      Washington, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spinster gene function is required in a subset of brain neurons for acquiring sexual receptivity in female Drosophila2009

    • Author(s)
      Sakurai, A., Nakano, Y., Koganezawa, M., Yamamoto, D.
    • Organizer
      Cold Spring Harbor Laboratory Neurobiology of Drosophila
    • Place of Presentation
      New York, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sexually dimorphic fruitless-expressing interneurons shape male courtship posture in Drosophila2009

    • Author(s)
      小金澤雅之, 山元大輔
    • Organizer
      The 32^<nd> Annual Meeting the Japan Neuroscience Society
    • Place of Presentation
      Nagoya
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of chromatin regulators HP1 and Rpd3 on the formation of sexually dimorphic neuronal circuitry in the Drosophila CNS2009

    • Author(s)
      Ito, H., Koganezawa, M., Ote, M., Matsumoto, K., Tateno, M., Hama, C., Yamamoto, D.
    • Organizer
      The 2^<nd> Brain Science Summer Retreat "How to research unsolved problems"(Tohoku Neuroscience GCOE)
    • Place of Presentation
      Tohoku University, Sendai
    • Related Report
      2009 Annual Research Report
  • [Presentation] The analysis of female sexual receptivity with special reference to spinster, a mutation that causes enhanced mate refusal in female Drosophila2009

    • Author(s)
      Sakurai, A., Nakano, Y., Koganezawa, M., Yamamoto, D.
    • Organizer
      The 9^<th> Japanese Drosophila Research Conference
    • Place of Presentation
      Kakegawa
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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