Identification of transporters involved in bittern excretion in marine teleost fish

• Project/Area Number: 21770077
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Animal physiology/Animal behavior
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: KATO Akira Tokyo Institute of Technology, 大学院・生命理工学研究科, 助教 (40311336)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 生理学 / 遺伝子 / 海水適応 / フグゲノム / イオントランスポーター / 尿細管 / 近位尿細管 / 近位尿細管尿細管

Research Abstract

In marine teleost fish, dehydration is avoided through continuous drinking of seawater (SW) and subsequent elimination of excess, acquired ions from the gill (Na^+, Cl^-), intestine (Ca^<2+>, Mg^<2+>), and kidney (Mg^<2+>, SO_4^<2->, borate, Ca^<2+>). By the expression and functional analyses of ion transporters in the fugu kidney using fugu genome database, we identified ion transporters involved in renal excretion of SO_4^<2->, borate, and Ca^<2+>.

Research Products

• [Journal Article] Regulation of electroneutral NaCl absorption by the small intestine. (2011)
  • Author(s): Kato A, Romero MF.
  • Journal Title: Annu Rev Physiol 73 Pages: 261-281
• [Journal Article] Differential expression of Na^+-Cl^- cotransporter and Na^+-K^+-Cl^- cotransporter 2 in the distal nephrons of euryhaline and seawater pufferfishes. (2011)
  • Author(s): Kato A, Muro T, Kimura Y, Li S, Islam Z, Ogoshi M, Doi H, Hirose S.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol 300
  • Peer Reviewed
• [Journal Article] Regulation of electroneutral NaCl absorption by the small intestine (2011)
  • Author(s): Kato A, Romero MF
  • Journal Title: Annu Rev Physiol Volume: 73 Pages: 261-281
• [Journal Article] Differential expression of Na^+-Cl^- cotransporter and Na^+-K^+-Cl^- cotransporter 2 in the distal nephrons of euryhaline and seawater pufferfishes (2011)
  • Author(s): Kato A., Muro T, Kimura Y, Li S, Islam Z, Ogoshi M, Doi H, Hirose S
  • Journal Title: Am J Physiol Regul Integr Comp Physiol Volume: 300
  • Peer Reviewed
• [Journal Article] Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammonia exposure. (2010)
  • Author(s): Nawata CM, Hirose S, Nakada T, Wood CM, Kato A.
  • Journal Title: J Exp Biol 213 Pages: 3150-3160
  • Peer Reviewed
• [Journal Article] Brief migration of the grass puffer, Takifugu niphobles, to fresh water from salt water. (2010)
  • Author(s): Kato A, Maeno T, Hirose S.
  • Journal Title: Ichthyol Res 57(3) Pages: 298-304
  • NAID: 10026514613
  • Peer Reviewed
• [Journal Article] Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammonia exposure (2010)
  • Author(s): Nawata CM, Hirose S, Nakada T, Wood CM, Kato A
  • Journal Title: J Exp Biol Volume: 213 Pages: 3150-3160
  • Peer Reviewed
• [Journal Article] Brief migration of the grass puffer, Takifugu niphobles, to fresh water from salt water (2010)
  • Author(s): Kato A, Maeno T, Hirose S
  • Journal Title: Ichthyol Res Volume: 57 Pages: 298-304
  • NAID: 10026514613
  • Peer Reviewed
• [Journal Article] Brief migration of the grass puffer, Takifugu niphobles, to fresh water from salt water (2010)
  • Author(s): Kato A, Maeno T, Hirose S
  • Journal Title: Ichthyol Res (In press)
  • NAID: 10026514613
  • Peer Reviewed
• [Journal Article] Identification of renal transporters involved in sulfate excretion in marine teleost fish. (2009)
  • Author(s): Kato A, Chang MH, Kurita Y, Nakada T, Ogoshi M, Nakazato T, Doi H, Hirose S, Romero MF.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol 297
  • Peer Reviewed
• [Journal Article] Identification of renal transporters involved in sulfate excretion in marine teleost fish (2009)
  • Author(s): Kato A, Chang MH, Kurita Y, Nakada T, Ogoshi M, Nakazato T, Doi H, Hirose S, Romero MF
  • Journal Title: Am J Physiol Regul Integr Comp Physiol 297
  • Peer Reviewed
• [Presentation] Mechanism of Borate Secretion by the Kidney of Seawater Fish. (2010)
  • Author(s): Kimura Y, Kurita Y, Kato A, Doi H, Hirose S.
  • Organizer: The 5th TOIN International Symposium on Biomedical Engineering
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2010-11-06
• [Presentation] Expression analysis of Mg^2+ transporters in the kidney of marine and euryhaline pufferfishes. (2010)
  • Author(s): Islam Z, Kato A, Hirose S.
  • Organizer: The 5th TOIN International Symposium on Biomedical Engineering
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2010-11-06
• [Presentation] Mechanism of Borate Secretion by the Kidney of Seawater Fish (2010)
  • Author(s): Kimura Y, Kurita Y, Kato A, Doi H, Hirose S
  • Organizer: The 5^<th> TOIN International Symposium on Biomedical Engineering
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2010-11-06
• [Presentation] Expression analysis of Mg^<2+> transporters in the kidney of marine and euryhaline pufferfishes (2010)
  • Author(s): Islam Z, Kato A, Hirose S
  • Organizer: The 5^<th> TOIN International Symposium on Biomedical Engineering
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2010-11-06
• [Presentation] Molecular Physiology of Ammonia Excretion in the Pufferfish (Takifugu rubripes). (2010)
  • Author(s): Nawata CM, Hirose S, Nakada T, Wood CM, Kato A.
  • Organizer: The Society for Experimental Biology (SEB) Meeting 2010
  • Place of Presentation: Prague, Czech
  • Year and Date: 2010-06-30
• [Presentation] Molecular Physiology of Ammonia Excretion in the Pufferfish (Takifugu rubripes) (2010)
  • Author(s): Nawata CM, Hirose S, Nakada T, Wood CM, Kato A
  • Organizer: The Society for Experimental Biology (SEB) Meeting 2010
  • Place of Presentation: Prague, Czech
  • Year and Date: 2010-06-30
• [Presentation] Pufferfish Slc26a5 (prestin) exchanges Cl^- for oxalate, sulfate, and bicarbonate. (2010)
  • Author(s): Hirata T, Kato A, Chang MH, Hirose S, Romero MF.
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, USA
  • Year and Date: 2010-04-06
• [Presentation] Pufferfish Slc26a5 (prestin) exchanges Cl^- for oxalate, sulfate, and bicarbonate (2010)
  • Author(s): Hirata T, Kato A, Chang MH, Hirose S, Romero MF
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, USA
  • Year and Date: 2010-04-06
• [Presentation] Identification of kidney magnesium transporters in marine teleost fish. (2009)
  • Author(s): Islam Z, Kato A, Hirose S.
  • Organizer: The 4th TOIN International Symposium on Biomedical Engineering
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2009-10-30
• [Presentation] Excretion of Borate by the Kidney of Seawater Fish. (2009)
  • Author(s): Kimura Y, Kurita Y, Kato A, Doi H, Hirose S.
  • Organizer: The 36th Congress of the International Union of Physiological Sciences.
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-08-01
• [Remarks] ホームページ
  • URL: http://www.hirose.bio.titech.ac.jp/
• [Remarks] 米国生理学会(The American Physiological Society, APS)の比較進化生理学部門で,New Investigator Awardを受賞(2011年2月15日)
  • URL: http://www.titech.ac.jp/topics/news/detail_1713.html?id=topics
• [Remarks]
  • URL: http://www.hirose.bio.titech.ac.jp/
• [Remarks]
  • URL: http://www.titech.ac.jp/topics/news/detail_1713.html?id=topics