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Identification and functional analysis of novel hypothalamic neuropeptides involved in energy homeostasis.

Research Project

Project/Area Number 21770079
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Animal physiology/Animal behavior
Research InstitutionHiroshima University

Principal Investigator

IWAKOSHI Eiko  広島大学, 大学院・総合科学研究科, 研究員 (50311296)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経ペプチド / 鳥類 / 視床下部 / 摂食行動 / 新規遺伝子 / 組換えタンパク質 / 形態解析 / 生理作用 / 受容体 / 摂食中枢 / 質量分析
Research Abstract

Recently, many neuropeptides involved in food intake have been identified in mammals and extensive studies have been performed to reveal their physiological functions. However, there are little studies on these neuropeptides in non-mammals. In this study, firstly we sought the novel RFamide peptide, 26RFa, in the avian species, as the aspect of energy homeostasis. In addition, we further investigated a novel precursor gene encoding neuropeptide which we have originally identified in the avian brain.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (4 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Identificationand structure-activity relationship of anantimicrobial peptide of the palustrin-2family isolated from the skin of theendangered frog Odorrana ishikawae2011

    • Author(s)
      Iwakoshi-Ukena E, Okada G, Okimoto A, Fujii T, Sumida M, Ukena K.
    • Journal Title

      Peptides

      Volume: 32 Pages: 2052-2057

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization ofnovel antimicrobial peptides from the skin ofthe endangered frog Odorrana ishikawae byshotgun cDNA cloning. Biochem. Biophys2011

    • Author(s)
      Iwakoshi-Ukena E, Soga M, Okada G, FujiiT, Sumida M, Ukena K.
    • Journal Title

      Res. Commun.

      Volume: 412 Pages: 673-677

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification andcharacterization of antimicrobial peptidesfrom the skin of the endangered frogOdorrana ishikawae2011

    • Author(s)
      Iwakoshi-Ukena E, Ukena K, Okimoto A, Soga M, Okada G, Sano N, Fujii T, Sugawara Y, Sumida M.
    • Journal Title

      Peptides

      Volume: 32 Pages: 670-676

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and structure-activity relationship of an antimicrobial peptide of the palustrin-2 family isolated from the skin of the endangered frog Odorrana ishikawae2011

    • Author(s)
      Iwakoshi-Ukena E
    • Journal Title

      Peptides

      Volume: 32 Issue: 10 Pages: 2052-2057

    • DOI

      10.1016/j.peptides.2011.08.024

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning2011

    • Author(s)
      Iwakoshi-Ukena E
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 412 Issue: 4 Pages: 673-677

    • DOI

      10.1016/j.bbrc.2011.08.023

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae2011

    • Author(s)
      Iwakoshi-Ukena E
    • Journal Title

      Peptides

      Volume: 32 Issue: 4 Pages: 670-676

    • DOI

      10.1016/j.peptides.2010.12.013

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification, localization, and function of anovel avian hypothalamic neuropeptide, 26RFa, and its cognate receptor, Gprotein-coupled receptor-1032010

    • Author(s)
      Ukena K, Tachibana T, Iwakoshi-Ukena E, Saito Y, Minakata H, Kawaguchi R, Osugi T, Tobari Y, Leprince J, Vaudry H, Tsutsui K.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 2255-2264

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification, localization, and function of a novel avian hypothalamic neuropeptide, 26RFa, and its cognate receptor, G protein-coupled receptor-103.2010

    • Author(s)
      Ukena K
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 2255-2264

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ニワトリの新規摂食調節関連遺伝子がコードしている神経ペプチドの摂食行動に及ぼす影響2011

    • Author(s)
      岩越栄子
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      東京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 視床下部における新規摂食調節関連遺伝子の発見2010

    • Author(s)
      岩越栄子、田中幸恵、橘哲也、浮穴和義
    • Organizer
      第35回日本比較内分泌学会大会静岡
    • Place of Presentation
      静岡
    • Year and Date
      2010-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 視床下部における新規摂食調節関連遺伝子の発見2010

    • Author(s)
      岩越栄子
    • Organizer
      第35回日本比較内分泌学会大会
    • Place of Presentation
      静岡市
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] ニワトリの新規摂食調節関連遺伝子がコードしている神経ペプチドの摂食行動に及ぼす影響2010

    • Author(s)
      岩越栄子、橘哲也、古満芽久美、浮穴和義
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-20
    • Related Report
      2011 Final Research Report
  • [Remarks] 2010年の第35回日本比較内分泌学会大会において口頭発表した内容に対し、若手研究者最優秀発表賞を受賞した。

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] ポリペプチド、ポリペプチドの製造方法、摂食調節組成物および摂食量の調節方法2011

    • Inventor(s)
      浮穴和義、岩越栄子、益田恵子、古満芽久美
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      2011-248006
    • Filing Date
      2011-11-11
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] ポリペプチド、摂食促進組成物および摂食量の促進方法2011

    • Inventor(s)
      浮穴和義、岩越栄子
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      2011-065216
    • Filing Date
      2011-03-24
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] ポリペプチド、ポリペプチドの製造方法、摂食調節組成物および摂食量の調節方法2011

    • Inventor(s)
      浮穴和義・岩越栄子・益田恵子・古満芽久美
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      2011-248006
    • Filing Date
      2011-11-11
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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