Structural and functional analysis of Uro-adherence factor A(UafA) from Staphylococcus saprophyticus
| Project/Area Number |
21770101
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 接着因子 / 結晶構造解析 / 腐性ブドウ球菌 |
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| Research Abstract |
Pathogenic bacteria express several cell wall-anchored proteins to adhere to the surface of host cell, whereas Staphylococcus saprophyticus, a uropathogen involved in urinary tract infection of young females, possesses a unique cell wall-anchored protein, UafA. In this study, we investigated the adhesion mechanism of UafA by structure analysis and biochemical assay.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Molecular basis of dihydrouridine formation on tRNA2011
Author(s)
Futao Yu, Yoshikazu Tanaka, Keitaro Yamashita, Takeo Suzuki, Akiyoshi Nakamura, Nagisa Hirano, Tsutomu Suzuki, Min Yao, and Isao Tanaka
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Journal Title
Proceedings of the National Academy of Sciences of the United States of America
Volume: 108
Pages: 19593-19598
Related Report
Peer Reviewed
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