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Structural study of the cell adhesion regulated by tension

Research Project

Project/Area Number 21770114
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Structural biochemistry
Research InstitutionNara Institute of Science and Technology

Principal Investigator

HIRANO Yoshinori  奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (50452529)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords細胞接着 / メカノバイオロジー / 張力センサー / カテニン / 分子複合体 / 結晶構造解析 / 張力 / 力学センサー / X線結晶構造解析
Research Abstract

Structural studies of ・-Catenin especially focused on its novel function as a mechanosensor are promoted. As the result, we succeeded in visualizing the tension-dependent interaction between ・-Catenin and Vinculin at an atomic resolution. These results clarified the ・-Catenin mediated tension sensing mechanism, which converts physical information into biochemical reactions represented by a molecular recognition.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (28 results)

All 2011 2010 2009 2008

All Journal Article (12 results) (of which Peer Reviewed: 4 results) Presentation (16 results)

  • [Journal Article] Structural basis of cargo recogniti-on bythe myosin-X MyTH4-FERM domain.2011

    • Author(s)
      Hirano,Y., Hatano,T., Takahashi,A., Toriyama,M., Inagaki,N. Hakoshima,T.
    • Journal Title

      EMBO J.

      Volume: 30 Pages: 2734-2747

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 植物ホルモンによって誘導されるタンパク質分解のメカニズム2011

    • Author(s)
      村瀬浩司, 平野良憲, 箱嶋敏雄
    • Journal Title

      実験医学

      Volume: 29 Pages: 1989-1994

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Journal Article] 植物ホルモンの受容とシグナル伝達の構造基盤2011

    • Author(s)
      西村宜之, 平野良憲, 人見研一, 箱嶋敏雄, 村瀬浩司
    • Journal Title

      化学と生物

      Volume: 49 Pages: 161-169

    • NAID

      10027898596

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Journal Article] Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain2011

    • Author(s)
      Hirano, Y., Hatano, T., Takahashi, A., Toriyama, M., Inagaki, N., Hakoshima, T.
    • Journal Title

      EMBO J

      Volume: 30 Pages: 2734-2747

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization of the plant hormone receptors PYL9/RCAR1, PYL5/RCAR8 and PYR1/RCAR11 in the presence of (+)- abscisic acid.2010

    • Author(s)
      Shibata,N., Kagiyama,M., Nakagawa,M, Hirano,Y., Hakoshima,T.
    • Journal Title

      Acta Crystallogr Sect F Struct Biol Cryst Commun

      Volume: 60 Pages: 456-459

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of Hormone and Effector Recognition by the Gibberellin Receptor2010

    • Author(s)
      Hirano,Y., Murase,K., Hakoshima,T.
    • Journal Title

      SPring-8 Research Frontiers

      Pages: 24-25

    • Related Report
      2010 Final Research Report
  • [Journal Article] ジベレリンの受容と情報伝達の分子メカニズム2010

    • Author(s)
      村瀬浩司, 平野良憲, 箱嶋敏雄
    • Journal Title

      植物の生長調節

      Volume: 45 Pages: 40-48

    • NAID

      110007641952

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Journal Article] Crystallization of the plant hormone receptors PYL9/RCAE1, PYL5/RCAR8 and PYR1/RCAR11 in the presence of (+)-abscisic acid2010

    • Author(s)
      Shibata, N., Kagiyama, M., Nakagawa, M, Hirano, Y., Hakoshima, T.
    • Journal Title

      Acta Crystallogr Sect F Struct Biol Cryst Commun

      Volume: 66 Pages: 456-459

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of Hormone and Effector Recognition by the Gibberellin Receptor2010

    • Author(s)
      Hirano, Y., Murase, K., Hakoshima, T.
    • Journal Title

      SPring-8 Research Frontiers

      Pages: 24-25

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 植物によるジベレリンの感知とシグナル伝達2009

    • Author(s)
      箱嶋敏雄, 平野良憲, 村瀬浩司, Tai-ping Sun
    • Journal Title

      生物物理

      Volume: 49 Pages: 200-201

    • NAID

      10025975787

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] 植物ホルモン受容体によるシグナル伝達制御の構造研究2009

    • Author(s)
      平野良憲, 村瀬浩司, 箱嶋敏雄
    • Journal Title

      蛋白質核酸酵素

      Volume: 54 Pages: 833-842

    • NAID

      40016675782

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] ジベレリン受容体GID1によるジベレリン認識とその分子進化2009

    • Author(s)
      箱嶋敏雄, 村瀬浩司, 平野良憲, Tai-ping Sun
    • Journal Title

      日本結晶学会誌

      Volume: 52 Pages: 37-37

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain.2011

    • Author(s)
      Hirano, Y., Hatano, T., Takahashi, A., Toriyama, M., Inagaki, N., Hakoshima, T.
    • Organizer
      XXII Congress and General Assembly of the International Union of Crystallography
    • Place of Presentation
      マドリッド(スペイン)
    • Year and Date
      2011-08-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain2011

    • Author(s)
      Hirano, Y., Hatano, T, Takahashi, A., Toriyama, M., Inagaki, N., Hakoshima, T.
    • Organizer
      XXII Congress and General Assembly of the International Union of Crystallography
    • Place of Presentation
      マドリッド(スペイン)
    • Year and Date
      2011-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Myosin-X のMyTH4-FERM ドメインによる積み荷認識機構の構造的基盤2011

    • Author(s)
      平野良憲, 畑野大樹, 高橋彩, 箱嶋敏雄
    • Organizer
      第11回 日本蛋白質科学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-07
    • Related Report
      2010 Final Research Report
  • [Presentation] ジベレリン受容体のジベレリン識別とエフェクター認識の構造的基礎2009

    • Author(s)
      箱嶋敏雄, 村瀬浩司, 平野良憲, Tai-ping Sun
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] ジベレリン受容体のジベレリン識別とエフェクター認識の構造的基礎2009

    • Author(s)
      箱嶋敏雄, 村瀬浩司, 平野良憲, Tai-ping Sun
    • Organizer
      第32回日本分子生物学会年会 ワークショップ「翻訳後修飾・分解による細胞制御の構造生物学の最前線」
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 張力による細胞接着制御機構の解明に向けたαカテニンの構造研究2009

    • Author(s)
      平野良憲, 米村重信, 箱嶋敏雄
    • Organizer
      特定領域研究「生体超分構造」 第6回公開シンポジウム
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府)
    • Year and Date
      2009-12-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 張力による細胞接着制御機構の解明に向けたαカテニンの構造研究2009

    • Author(s)
      平野良憲, 米村重信, 箱嶋敏雄
    • Organizer
      特定領域研究「生体超分構造」第6回公開シンポジウム
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府)
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 植物ホルモン受容体によるシグナル伝達制御の構造的基盤2009

    • Author(s)
      平野良憲, 村瀬浩司, Tai-ping Sun, 箱嶋敏雄
    • Organizer
      特定領域研究「生体超分子の構造形成と機能制御の原子機構」 第5回ワークショップ
    • Place of Presentation
      湘南国際村センター, 国際会議場(神奈川県)
    • Year and Date
      2009-07-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 植物ホルモン受容体によるシグナル伝達制御の構造的基盤2009

    • Author(s)
      平野良憲, 村瀬浩司, Tai-ping Sun, 箱嶋敏雄
    • Organizer
      特定領域研究「生体超分子の構造形成と機能制御の原子機構」第5回ワークショップ
    • Place of Presentation
      湘南国際村センター国際会議場(神奈川県)
    • Year and Date
      2009-07-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Structure-function analysis of GA receptor and DELLA protein in Arabidopsis2009

    • Author(s)
      Murase, K., Rodolfo, Z., Hirano, Y., Hu, J., Olszewski, N., Jeong, S.Y., Hakoshima, T., Sun, T.P.
    • Organizer
      Plant Biology 2009 (Joint Annual Meetings of the American Society of Plant Biologists and the Phycological Society of America)
    • Place of Presentation
      ホノルル(アメリカ合衆国)
    • Year and Date
      2009-07-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Structure-function analysis of GA receptor and DELLA protein in Arabidopsis2009

    • Author(s)
      Koji Murase, Zentella Rodolfo, Yoshinori Hirano, Jianhong Hu, Neil Olszewski, Sun Yong Jeong, Toshio Hakoshima, Tai-ping Sun
    • Organizer
      Plant Biology 2009 (Joint Annual Meetings of the American Society of Plant Biologists and the Phycological Society of America)
    • Place of Presentation
      アメリカ合衆国(ホノルル)
    • Year and Date
      2009-07-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanism of gibberellin perception and DELLA protein recognition by the Arabidopsis gibberellin receptor2009

    • Author(s)
      Murase, K., Hirano, Y., Sun, T.P., Hakoshima, T.
    • Organizer
      Plant Biology 2009 (Joint Annual Meetings of the American Society of Plant Biologists and the Phycological Society of America)
    • Place of Presentation
      ホノルル(アメリカ合衆国)
    • Year and Date
      2009-07-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Mechanism of gibberellin perception and DELLA protein recognition by the Arabidopsis gibberellin receptor2009

    • Author(s)
      Koji Murase, Yoshinori Hirano, Tai-ping Sun, Toshio Hakoshima
    • Organizer
      Plant Biology 2009 (Joint Annual Meetings of the American Society of Plant Biologists and the Phycological Society of America)
    • Place of Presentation
      アメリカ合衆国(ホノルル)
    • Year and Date
      2009-07-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 植物核内受容体の作用機構2009

    • Author(s)
      村瀬浩司, 平野良憲, Tai-ping Sun, 箱嶋敏雄
    • Organizer
      日本農芸化学会2009 年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] ジベレリンとその受容体、およびDELLA タンパク質複合体の結晶構造2009

    • Author(s)
      村瀬浩司, 平野良憲, Tai-ping Sun, 箱嶋敏雄
    • Organizer
      第50回日本植物生理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-22
    • Related Report
      2010 Final Research Report
  • [Presentation] ジベレリン受容体GID1 によるDELLA タンパク質認識の構造的基盤2008

    • Author(s)
      平野良憲, 村瀬浩司, Tai-ping Sun, 箱嶋敏雄
    • Organizer
      第31回分子生物学会年会, 第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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