Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Research Abstract |
Structural studies of ・-Catenin especially focused on its novel function as a mechanosensor are promoted. As the result, we succeeded in visualizing the tension-dependent interaction between ・-Catenin and Vinculin at an atomic resolution. These results clarified the ・-Catenin mediated tension sensing mechanism, which converts physical information into biochemical reactions represented by a molecular recognition.
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