Structural study of the cell adhesion regulated by tension
| Project/Area Number |
21770114
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
HIRANO Yoshinori 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (50452529)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 細胞接着 / メカノバイオロジー / 張力センサー / カテニン / 分子複合体 / 結晶構造解析 / 張力 / 力学センサー / X線結晶構造解析 |
|---|
| Research Abstract |
Structural studies of ・-Catenin especially focused on its novel function as a mechanosensor are promoted. As the result, we succeeded in visualizing the tension-dependent interaction between ・-Catenin and Vinculin at an atomic resolution. These results clarified the ・-Catenin mediated tension sensing mechanism, which converts physical information into biochemical reactions represented by a molecular recognition.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Structural basis of cargo recogniti-on bythe myosin-X MyTH4-FERM domain.2011
Author(s)
Hirano,Y., Hatano,T., Takahashi,A., Toriyama,M., Inagaki,N. Hakoshima,T.
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Journal Title
EMBO J.
Volume: 30
Pages: 2734-2747
Related Report
Peer Reviewed
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[Journal Article] Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain2011
Author(s)
Hirano, Y., Hatano, T., Takahashi, A., Toriyama, M., Inagaki, N., Hakoshima, T.
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Journal Title
EMBO J
Volume: 30
Pages: 2734-2747
Related Report
Peer Reviewed
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[Journal Article] Crystallization of the plant hormone receptors PYL9/RCAR1, PYL5/RCAR8 and PYR1/RCAR11 in the presence of (+)- abscisic acid.2010
Author(s)
Shibata,N., Kagiyama,M., Nakagawa,M, Hirano,Y., Hakoshima,T.
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Journal Title
Acta Crystallogr Sect F Struct Biol Cryst Commun
Volume: 60
Pages: 456-459
Related Report
Peer Reviewed
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[Journal Article] Crystallization of the plant hormone receptors PYL9/RCAE1, PYL5/RCAR8 and PYR1/RCAR11 in the presence of (+)-abscisic acid2010
Author(s)
Shibata, N., Kagiyama, M., Nakagawa, M, Hirano, Y., Hakoshima, T.
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Journal Title
Acta Crystallogr Sect F Struct Biol Cryst Commun
Volume: 66
Pages: 456-459
Related Report
Peer Reviewed
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[Presentation] Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain.2011
Author(s)
Hirano, Y., Hatano, T., Takahashi, A., Toriyama, M., Inagaki, N., Hakoshima, T.
Organizer
XXII Congress and General Assembly of the International Union of Crystallography
Place of Presentation
マドリッド(スペイン)
Year and Date
2011-08-24
Related Report
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[Presentation] Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain2011
Author(s)
Hirano, Y., Hatano, T, Takahashi, A., Toriyama, M., Inagaki, N., Hakoshima, T.
Organizer
XXII Congress and General Assembly of the International Union of Crystallography
Place of Presentation
マドリッド(スペイン)
Year and Date
2011-08-24
Related Report
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[Presentation] Structure-function analysis of GA receptor and DELLA protein in Arabidopsis2009
Author(s)
Murase, K., Rodolfo, Z., Hirano, Y., Hu, J., Olszewski, N., Jeong, S.Y., Hakoshima, T., Sun, T.P.
Organizer
Plant Biology 2009 (Joint Annual Meetings of the American Society of Plant Biologists and the Phycological Society of America)
Place of Presentation
ホノルル(アメリカ合衆国)
Year and Date
2009-07-20
Related Report
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