Regulation of peroxisome matrix protein import by ubiquitin modification
Project/Area Number |
21770117
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Structural biochemistry
|
Research Institution | Kyushu University |
Principal Investigator |
OKUMOTO Kanji Kyushu University, 大学院・理学研究院, 助教 (20363319)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 細胞内小器官 / ユビキチン化 / タンパク質輸送 / 翻訳後修飾 / ペルオキシソーム |
Research Abstract |
Peroxisome, one of the intracellular organelle, includes various physiological functions and the deficiency causes fetal genetic diseases in human. This study clarified that import of peroxisomal matrix proteins into peroxisomes, the most important process in peroxisome biogenesis, is elaborately regulated by unique ubiquitin modification of Pex5p, a cytosolic receptor of peroxisome targeting signal type-1.
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Report
(3 results)
Research Products
(12 results)