• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Regulation of peroxisome matrix protein import by ubiquitin modification

Research Project

Project/Area Number 21770117
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Structural biochemistry
Research InstitutionKyushu University

Principal Investigator

OKUMOTO Kanji  Kyushu University, 大学院・理学研究院, 助教 (20363319)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords細胞内小器官 / ユビキチン化 / タンパク質輸送 / 翻訳後修飾 / ペルオキシソーム
Research Abstract

Peroxisome, one of the intracellular organelle, includes various physiological functions and the deficiency causes fetal genetic diseases in human. This study clarified that import of peroxisomal matrix proteins into peroxisomes, the most important process in peroxisome biogenesis, is elaborately regulated by unique ubiquitin modification of Pex5p, a cytosolic receptor of peroxisome targeting signal type-1.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Remarks (3 results)

  • [Journal Article] Cysteine-ubiquitination of peroxisome-targeting-signal type 1 (PTS1)-receptor Pex5p regulates Pex5p import and export

    • Author(s)
      奥本寛治、美園紗知、宮田暖、松元由依、向井悟、藤木幸夫
    • Journal Title

      Traffic in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Functional roles of two serine proteaases, Tysnd1 and PsLon2010

    • Author(s)
      奥本寛治、亀谷紫、藤木幸夫
    • Organizer
      in peroxisome matrix The 3rd International Symposium on Protein Community
    • Place of Presentation
      日航ホテル奈良(奈良市)
    • Year and Date
      2010-09-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization of peroxisome membrane protein TMEM135/PMP522010

    • Author(s)
      奥本寛治、藤木幸夫
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規ペルオキシソーム膜タンパク質TMEM135/PMP52の機能解析2010

    • Author(s)
      奥本寛治、藤木幸夫
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] The complex of RING peroxins, Pex10p and Pex12p, functions as an ubiquitin ligase for the PTS1 receptor Pex5p and regulates peroxisomal matrix protein import2009

    • Author(s)
      奥本寛治、野田浩美、藤木幸夫
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] The complex of RING peroxis, Pex10p and Pex12p, fuctions as an ub iquitin ligase for the PTS1 receptor Pex5p and regulates peroxisomal matrix protein import.2009

    • Author(s)
      奥本寛治、野田浩美、藤木幸夫
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] The complex of RING peroxins, Pex10p and Pex12p, ubiquitinates the PTS1 receptor Pex5p and regulates import of peroxisomal matrix proteins2009

    • Author(s)
      奥本寛治、野田浩美、藤木幸夫
    • Organizer
      International meeting on peroxisome research
    • Place of Presentation
      Institute forSystem Biology(シアトル、米国)
    • Year and Date
      2009-11-19
    • Related Report
      2010 Final Research Report
  • [Presentation] RING ペルオキシンPex10p-Pex12p複合体はPTS1レセプターPex5pをユビキチン化し、Pex5p のペルオキシソーム-細胞質間のシャトリングを制御する2009

    • Author(s)
      奥本寛治、野田浩美、藤木幸夫
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2009-06-03
    • Related Report
      2010 Final Research Report
  • [Presentation] PINGペルオキシンPex10p-Pex12p複合体PTS1レセプターPex5pをユビキチン化し、Pex5pのペルオキシソーム-細胞質間のシャトリングを制御する。2009

    • Author(s)
      奥本寛治、野田浩美、藤木幸夫
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.biology.kyushu-u.ac.jp/%7Etaisha/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.biology.kyushu-u.ac.jp/~taisha/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.biology.kyushu-u.ac.jp/~taisha/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi