| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
NMR relaxation dispersion studies revealed that Sox2 fluctuates when it is free in solution, in particular the N-terminal helix α1 and the regions contacting the helixα1 are unfolded with a population of 2%. In contrast, no relaxation dispersion was observed for Sox2 in the bound form, indicating that Sox is stable in the bound form on μs-ms timescales. Since the helix α1 binds directly to DNA, the fluctuation observed for the free form is supposed to be important for non-specific binding to DNA.
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