analysis of lysophospholipid signaling in zebrafish
| Project/Area Number |
21770131
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
HAMA Kotaro 東北大学, 大学院・薬学研究科, 助教 (20534481)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | リゾホスファチジン酸 / 受容体 / 産生酵素 / ゼブラフィッシュ / リゾリン脂質 |
|---|
| Research Abstract |
The aim of this study is clarifying the molecular machinery of lysophospholipid signaling using zebrafish. We first modified several vectors using gal4-UAS system and transposon (tol2) to facilitate making transgenic lines. Using this vectors, we succeeded in establishing several transgenic lines. These are useful tools to elucidate the timing and the place in which lysophospholipid signaling functions. We succeeded in discovering several genes involved in some organogenesis. Zebrafish is considered as the lowest model organisms which possesses lysophospholipid signaling related genes. Our study shows that zebafish as a useful model organisms to elucidate the lysophospholipid signaling in vivo.
|
Report
(3 results)
Research Products
(31 results)
-
-
-
-
-
-
-
-
[Journal Article] Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood2009
Author(s)
Endo T, Kano K, Motoki R, Hama K, Okudaira S, Ishida M, Ogiso H, Tanaka M, Matsuki N, Taguchi R, Kanai M, Shibasaki M, Arai H, Aoki J
-
Journal Title
Journal of Biochemistry 146
Pages: 283-93
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
