Regulation of post-translational modifications through fat-soluble ligands

• Project/Area Number: 21770134
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Functional biochemistry
• Research Institution: The University of Tokyo
• Principal Investigator: OHTAKE Fumiaki The University of Tokyo, 分子細胞生物学研究所, 助教 (60447373)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ユビキチン / 転写制御 / 環境 / 環境応答 / ダイオキシン受容体

Research Abstract

The data shows that ubiquitination and degradation of the dioxin receptor (AhR) are regulated by the histone acetyltransferase CBP.

Research Products

• [Journal Article] PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B. (2011)
  • Author(s): Baba A, Ohtake F, Okuno Y, Yokota K, Okada M, Imai Y, Ni M, Meyer CA, Igarashi K, Kanno J, Brown M, Kato S.
  • Journal Title: Nat Cell Biol. (published on line)
  • Peer Reviewed
• [Journal Article] Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system. (2011)
  • Author(s): Ohtake F, Fujii-Kuriyama Y, Kawajiri K, Kato S.
  • Journal Title: J Steroid Biochem Mol Biol. (published on line)
  • Peer Reviewed
• [Journal Article] Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system. (2011)
  • Author(s): Ohtake F, Fujii-Kuriyama Y, Kawajiri K, Kato S
  • Journal Title: J Steroid Biochem Mol Biol Volume: (Published on line)
  • Peer Reviewed
• [Journal Article] Hormonal gene regulation through DNA methylation and demethylation (2010)
  • Author(s): Kouzmenko, A, Ohtake, F, Fujiki, R, Kato S
  • Journal Title: EPIGENOMICS 2(6) Pages: 765-774
  • Peer Reviewed
• [Journal Article] Hormonal gene regulation through DNA methylation and demethylation (2010)
  • Author(s): Kouzmenko, A ; Ohtake, F ; Fujiki, R, Kato S
  • Journal Title: Epigenomics Volume: 2 Pages: 765-774
  • Peer Reviewed
• [Journal Article] DNA demethylation in hormone-induced transcriptional derepression. (2009)
  • Author(s): Yamamoto Y, Takahashi S, Matsumoto T, Fujiyama S, Shirode Y, Yamaoka I, Kitagawa H, Takeyama K, Shibuya H, Ohtake F, Kato S.
  • Journal Title: Nature. 461(7266) Pages: 1007-1012
  • Peer Reviewed
• [Journal Article] Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+mice with natural ligands. (2009)
  • Author(s): Kawajiri K, Kobayashi Y, Ohtake F, Ikuta T, Matsushima Y, Mimura J, Pettersson S, Pollenz RS, Sakaki T, Hirokawa T, Akiyama T, Kurosumi M, Poellinger L, Kato S, Fujii-Kuriyama Y.
  • Journal Title: Proc Natl Acad Sci U S A. 106(32) Pages: 13481-13486
  • Peer Reviewed
• [Journal Article] AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions. (2009)
  • Author(s): Ohtake F, Fujii-Kuriyama Y, Kato S.
  • Journal Title: Biochem Pharmacol. 77(4) Pages: 474-484
  • Peer Reviewed
• [Journal Article] DNA demethylation in hormone-induced transcriptional derepression (2009)
  • Author(s): Kim Mi-sun
  • Journal Title: Nature 461 Pages: 1007-1012
  • Peer Reviewed
• [Journal Article] Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands (2009)
  • Author(s): Kawajiri Kaname
  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 13481-13486
  • Peer Reviewed
• [Presentation] Ligand-selective poly-ubiquitin chain formation of AhR, a component of E3 complex (2010)
  • Author(s): Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: リーガロイヤルホテル、大阪
  • Year and Date: 2010-09-24
• [Presentation] Ligand-selective poly-ubiquitylation of AhR involves a transcriptional co-regulator CBP (2010)
  • Author(s): 大竹史明、加藤茂明
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸
• [Presentation] Ligand-selective poly-ubiquitin chain formation of AhR, a component of E3 complex (2010)
  • Author(s): Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪 シンポジウム
• [Presentation] A transcription factor, AhR, acts as a ligand-dependent E3 ubiquitin ligase (2010)
  • Author(s): Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
  • Organizer: Korea-Japan chromatin meeting
  • Place of Presentation: 韓国 国際シンポジウム
• [Presentation] A signal-dependent histone lysine demethylase complex (2009)
  • Author(s): 大竹史明
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] PHF2/ARID5B is a signal-dependent histone demethylase (2009)
  • Author(s): 大竹史明、藤井義明、加藤茂明
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜 シンポジウム
• [Presentation] Ah receptor acts as a ligand-dependent ubiquitin ligase (2009)
  • Author(s): Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
  • Organizer: 堀場・CDBIシンポジウム
  • Place of Presentation: 東京 国際シンポジウム
• [Presentation] AhR acts as a ligand-dependent E3 ubiquitin ligase (2009)
  • Author(s): 大竹史明、藤井義明、加藤茂明
  • Organizer: 日本生化学会
  • Place of Presentation: 大阪 シンポジウム
• [Presentation] Association of AhR with ER exerts adverse estrogen-related effects (2009)
  • Author(s): 大竹史明、藤井義明、加藤茂明
  • Organizer: 日本環境ホルモン学会
  • Place of Presentation: 東京
• [Book] 現代栄養学を理解するための分子生物学入門(5章 シグナル伝達)(加藤茂明・編) (2010)
  • Author(s): 大竹史明
  • Publisher: 光生館
• [Book] 転写制御とエピジェネティクス(第15章 核内受容体によるクロマチン転写の分子機構)(加藤茂明・編) (2008)
  • Author(s): 加藤茂明、藤木亮次、大竹史明
  • Publisher: 南山堂
• [Remarks] ホームページ等
  • URL: http://www.iam.u-tokyo.ac.jp/bnsikato/index.html