Analysis of themechanism for control the interaction between mitotic microtubules and dynamin.
Project/Area Number |
21770143
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Functional biochemistry
|
Research Institution | Hiroshima University |
Principal Investigator |
HAMAO Kozue 広島大学, 大学院・理学研究科, 准教授 (10403578)
|
Project Period (FY) |
2009 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,768,611 (Direct Cost: ¥3,668,163、Indirect Cost: ¥1,100,448)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥218,611 (Direct Cost: ¥168,163、Indirect Cost: ¥50,448)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 細胞骨格 / 細胞分裂 / 微小管 / ダイナミン / 相互作用 / SNX9 / EB1 / リン酸化 / Rhoキナーゼ / 結合タンパク質 |
Research Abstract |
To analyze the regulatory mechanisms for the dynamics of mitotic microtubules, I tried to elucidate the novel mechanisms for thebinding of dynamin to mitotic microtubules. I revealed that (1) phosphorylation of dynamin by Cyclin B-cdc2 kinase reduces the binding ability of dynamin to micorotubules (2) dynamin binds to SNX9 in interphasic cells (3) the microtubule binding domain of dynamin is the proline-rich domain (4) dynamin binds to dynamic microtubules
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Report
(4 results)
Research Products
(51 results)