Mechanisms involved in ghrelin degradation in circulation and identification of its processing enzymes.
| Project/Area Number |
21770149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Research Collaborator |
NISHI Yoshihiro 久留米大学, 医学部, 講師 (20352122)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | グレリン / 酵素 / ペプチドホルモン / 脂質修飾 / タンパク質精製 / 血液 / 食欲 / プロテインC |
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| Research Abstract |
A peptide hormone ghrein has divers physiological actions including growth hormone release, appetite control and immunomodulation. In this study, the ghrelin deacylation enzyme (APT1) and two ghrelin peptidases (APC and TAFI) were purified from animal blood, and their cDNAs were isolated. The enzymatic processed formsshowed synergistic or distinctive roles in ghrelin actions such as cell differentiation.
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Report
(5 results)
Research Products
(24 results)
